This comprehensive volume presents data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and dysregulation of ion channels and transporters in the ocular lens, among others. The concluding part is comprised of four chapters devoted to advancements in corneal surgery, cataract and diabetic retinopathy, the clinical treatment of cataracts including traumatic cataracts, and cataracts in the pediatric age group.

Studies on the Cornea and Lens is an essential addition to the library or department of physicians and scientists who treat or research these ocular conditions, particularly cataracts. It is also a key resource for cell biologists studying oxidative stress. This book is an authoritative contribution to Springer's Oxidative Stress in Applied Basic Research and Clinical Practice series.

Autorentext

Dr. Mark Babizhayev is a bio-physicist and holds a PhD in Biophysics and Pathophysiology from the Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia. He has dedicated many years to scientific research and has written more than 102 published articles and has fifteen patents to his name. The recipient of numerous awards, Dr. Babizhayev is currently Executive Director of Innovative Vision Products, Inc., Delaware, USA, Senior Research Investigator at Moscow Helmholtz Research Institute of Eye Diseases, and Scientific Consultant at EXSYMOL SAM, Monte Carlo, Monaco, and Bruschettini SRL, Genoa, Italy. He is also one of the principal researchers involved in the development of a breakthrough for the treatment and prevention of senile cataract.

Dr. David Wan-Cheng Li is an Associate Professor of Ophthalmology and Visual Sciences in the Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, an elected Lotus Scholar Professor of Cell and Developmental Biology of China's Hunan Normal University by Hunan Province Government, and a Visiting Professor of Ophthalmology and Visual Sciences in the State Key Laboratory in the Zhongshan Ophthalmic Center of Sun Yat-Sen University Medical Center, Guangzhou, China. He received his PhD from University of Washington, Seattle, USA, and completed his postdoctoral training at Columbia University, New York, USA. His scientific contributions include the major discoveries that stress-induced apopto sis acts as a common cellular mechanism for non-congenital cataract formation, that human hTERT is compatible with the RNA template from bovine and rabbit, and that different SUMOs have distinct functions in regulating cell differentiation. He received the outstanding cataract research award from National Foundation for Eye Research and the Lotus Scholar Contribution Award from Hunan Province Government. He is currently the Editor-in-Chief for Current Molecular Medicine.

Dr. Anne Kasus-Jacobi is Assistant Professor of Pharmaceutical Sciences and adjunct faculty in the Departments of Neuroscience and Physiology at the University of Oklahoma Health Sciences Center, Oklahoma City, USA. She was previously Assistant Professor of Ophthalmology at the Dean McGee Eye Institute in the University of Oklahoma Health Sciences Center. She received her PhD in Endocrinology from the University of Paris, France, and continued her postdoctoral training in the laboratory of Drs. Michael Brown and Joseph Goldstein at the University of Texas Southwestern Medical Center, Dallas, USA. Dr. Kasus-Jacobi's current interests include the development of innovative peptide treatments for corneal wounds and antibiotic-resistant bacterial infections. She is a member of the Association for Research in Vision and Ophthalmology and serves as an editorial board member of the Journal of Ocular Diseases and Therapeutics.

Dr. Lepa ori works in clinical ophthalmology on the Faculty of Medicine of University of Pristina, Serbia. She completed her PhD at the University of Pristina with a thesis on anti-oxidation status in aqueous humour, lens and serum of patients with age-related cataracts. A member of several international and national medical and neuro-ophthalmology societies, Dr. Zoric has presented or published more than 100 articles in both domestic and international journals.

Dr. Jorge L. Alió is Professor and Chairman of Ophthalmology at the Miguel Hernández University, Alicante, Spain, and formerly chairman of Ophthalmology at the University of Alicante, Spain. He has been appointed with several visiting professorships at universities in the United States and Europe. He attended the Complutense University of Madrid, Spain, where he received a medical degree and a PhD in biological thermodynamics and its application in the study of ophthalmic pathology. Recipient of the 2012 Lifetime Achievement Award from the International Society of Refractive Surgery, Dr. Alió's main research interests include refractive, lens and corneal surgery, ocular inflammation and preventative ophthalmology. His main contributions have been in the area of excimer laser refractive surgery, microincisional lens surgery, and multifocal accommodative and premium IOLs.

Inhalt

1 Oxidative Stress in Cornea .- 2 Corneal Degenerations.- 3 Corneal Epithelial Nuclear Ferritin and its Transporter Ferritoid Afford Unique Protection to DNA from U.V. Light and Reactive Oxygen Species.- 4 Excitatory Amino Acid Transporters, Xc- Antiporter, Glutamyl Transpeptidase, Glutamine Synthetase Activity and Glutathione in Human Corneal Epithelial Cells.- 5 Transforming Growth Factor 3 Regulates Cell Metabolism in Corneal Keratocytes and Fibroblasts.- 6 Corneal Stem Cells: a Source of Cell Renewal with Therapeutic Potential.- 7 New Agents for Treating Dry Eye Syndrome.- 8 Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells.- 9 Basic Review of the Oxidative Stress Role in Age-Related Cataractogenesis.- 10 The Human Lens: A living Biometric Indicator of Health Status and Successful Aging.- 11 Oxidative Stress in Lens.- 12 Protein Serine/Threonine Phosphatases-1 and 2A in Lens Development and Pathogenesis.- 13 Proteases in Lens and Cataract.- 14 Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System.- 15 p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation.- 16 Etiology and Prevention of Cataract.- 17 The Effects of Lutein in Preventing Cataract Progression.- 18 Antioxidant Defense Network in the Lens and Benefits of Glutathione Prodrugs in Cataracts.- 19 Updates and Advanc es in Corneal Surgery.- 20 Cataract and Diabetic Retinopathy.- 21 Traumatic Cataract-a Review.- 22 Cataract in Paediatric Age Group-a Review.