Studies in Natural Products Chemistry, Volume 14: Stereoselective Synthesis, Part I is a collection of discourses on the stereoselective synthesis of the anticancer anthrucycline antibiotics; tetramic acid antibiotics; 3-and 4-deoxyhexoses; polysaccharides; levoglucosenone as precursor to natural products; synthesis of oligoribonucleotides; and oxidation of guaiazulene. This volume deals with a broad range of natural products focusing on the synthesis of antibiotics and anticancer agents - anthracyclines, tetramic acid, taxodione, vinblastine, and vincristine. These aforementioned drugs are used for the treatment of cancer (anthracyclines) and Hodgkin's disease and childhood acute leukemia (vinblastine and vincristine). The importance of the latest developments in the stereocontrolled synthesis of polysaccharides is discussed as polysaccharides play a fundamental role in cell life and have many technical applications. The synthesis of bioactive carbohydrates 3- and 4-deoxy-hexoses is compared with the more occurring deoxyhexoses in nature such as the 2-deoxy, 6-deoxy, and 2,6-dideoxy-hexoses, because the former are rare compounds and useful tools in the study of biological and biochemical properties of mono- and oligosaccharides, glycoproteins, and antibiotics. Alkaloids derived from Apocynaceae are known for their medicinal properties; hence the synthetic approaches to vinblastine and vincristine are discussed. Because of the minute amounts available from herbal sources, efforts toward their chemical synthesis are given more reference. This book can be a useful reference for the organic chemists. Chemical researchers, pharmaceutical scientists, and professionals of bioorganic chemistry will likewise gain a lot from this collection.

Inhalt

Foreword
Preface
Contributors
Stereoselective Syntheses of Doxorubicin and Related Compounds
Total Synthesis of Nogalamycin Congeners and Their Related Compounds
Synthesis of the Tetramic Acid Antibiotics
The Syntheses of 3-And 4-Deoxy-Hexoses
Recent Developments In the Synthesis of Polysaccharides and Stereospecificity of Glycosylation Reactions
Levoglucosenone: A Versatile Carbohydrate Precursor for the Synthesis of Natural Products
Chemical Synthesis of Branched Oligoribonucleotides and Their Related Compounds
Oxidation Products of Guaiazulene and Other Azulenic Hydrocarbons
Syntheses of Hydroazulene Sesquiterpenes Via Rearrangement of Substituted Hydronaphthalene Precursors
A Chapter In Thujone Chemistry - from Waste By-Product to Natural Products and Related Compounds
The Total Synthesis of Eudesm-11-En-4-Ols
Asymmetric Synthesis Using Chiral Acetals from C2-Symmetric Diols and Its Application to Natural Product Synthesis
Asymmetric Synthesis of Some Natural Spiro Compounds Utilizing Chiral Sulfoxide Auxiliary
Asymmetric Construction of Versatile Chiral Building Blocks and Their Application to the Syntheses of Natural Products
Cationic Cyclopentannelation Reactions
Chiral Construction of Quaternary Carbons Through Additionelimination Process: Application to the Natural Product Syntheses
Organic Synthesis Using Hydrogen Atom Abstraction Reactions
Taxodione Synthetic Studies
Synthetic Studies In the Field of Indole Alkaloids. Part 2
Stereoselectivity In Synthesis and Biosynthesis of Lupine and Nitraria Alkaloids
Biomimetic Synthesis of Benzo [C] Phenanthridine Alkaloids from Protoberberines
Synthetic Approaches to Vinblastine and Vincristine - Anticancer Alkaloids of Catharanthus Roseus
Subject Index