The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop­ ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop. Indeed, at first glance the recovery of stem cells from cord blood has to be seen as separate from the attempts to achieve effective in utero therapy by stem cell trans­ plantation, because the first issue deals with an innovative stem cell source as an alternative to bone marrow, which is already spreading rapidly in medical practice, whereas the second topic is still strictly ex­ perimental and only investigated in medical centers with the appropri­ ate background. It is, however, not only justified, but helpful to com­ bine the two topics in one workshop and consequently to cover them in the same volume of the Ernst Schering Research Foundation Work­ shop series, because they are intimately related and both based on the new insights into the biology of stem cells. Professor Werner Arber, the Nobel Laureate from the University of Basel, pointed out in his In- Professor Dr. W. Holzgreve VI Preface The participants of the workshop troductory Lecture that our understanding of hematopoietic stem cells as descendents of totipotent cells and our current approaches to using them in post-and prenatal therapy have been furthered significantly by genetic engineering technologies which are "artificial contributions to the process of biologic evolution".

Inhalt

U. Kapp and R. Mertelsmann: Plasticity of Stem Cells; D. Trono: Lentiviral Vectors for the Genetic Modification of Hematopoietic Stem Cells; A.M. Müller, H. Geiger, G. Eichholz and F. Harder: Origin and Developmental Plasticity of Hematopoietic Stem Cells; P. Rubinstein and C.E. Stevens: The New York Blood Centers's Placental/ Umbilical Cord Blood Program. Experience with a 'new'Source of Hematopoietic Stem Cells for Transplantation; E. Wunder: Chances and Limits of Cord Blood Transplantion; K. Seelmann: Legal and Ethical Questions of Cord Blood Transplantations and Banking; Ch. Coutelle, M. Themis, H. Schneider, T. Kiserud, T. Cook, A.-M. Douar, M. Hanson, A. Pavirani, Ch. Rodeck: Fetal Somatic Gene Therapy- A Preventive Approach to the Treatment of Genetic Disease; D.V. Surbek, W. Holzgreve: Prenatal Transplantation of Hematopoietic Stem Cell: Overview; A. Luther-Wyrsch, C. Nissen, D. Surbek, W. Holzgreve, E. Costello, M. Thali, E. Buetti, A. Wodnar-Filipowicz: Fetal Hematopoietic Stem Cell: In Vitro Expan. and Transduction Using Lentiviral Vectors; M.J. Cowan, S,-H. Chou, A.F. Tarantal: Tolerance Induction Post In Utero Stem Cell Transplantation; J.-Wilpshaar, H.H.H. Kanhai, S. Scherjon, J.H.F. Falkenburg: Fetal Hematopoiesis during First and Second Trimester of Pregnancy: Relevance for In Utero Stem Cell Transplantation; D.R. Jones, E.M. Anderson, D.T.Y. Liu, and R. Walker: Tolerance Induction Following In Utero Stem Cell Transplantation; M. Westgren, L.E. Shields: In Utero Stem Transplantions in Humans;