The NATO-ASI conference Stem Cells and Their Potential for Clinical Application featured cutting-edge presentations ranging from laboratory research findings to the latest therapeutic applications. This book features contributions from many of the leading international scientists from North America and Western and Eastern Europe who participated in this conference. Articles cover a broad range of hot topics in stem cell and leukemia research.

Inhalt

I. HAEMATOPOIETIC STEM CELLS AND HAEMATOPOIESIS. Clonal Dominance After Reconstitution of the Haematopoietic System with Bone Marrow Cells Retrovirally Transduced with Murine CD34 Variants; G.von Keudell et al.- Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Self-Renewal of Early Hematopoietic Progenitor Cells; J. Friel et al.- Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cells (HSC) Compartment; O.I. Gan et al.- Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CDF Injections; I.N. Nifontova et al.- Regulation of Hematopoiesis by Growth Factors; E.R. Stanley.- II. BIOLOGY OF NON-HAEMATOPOIETIC STEM CELLS. Stem Cell Technologies in Gerontological Research; G.M. Butenko.- Osteopetrotic Models for Identifying Genes that Control Bone Resorption; W.Wiktor-Jedrzejczak.- Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine; C. Lange et al.- Epithelial Plasticity of Hepatocytes during Liver Tumor Progression; M. Mikula et al.- Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life; M. Crisan.- III. STEM CELLS AND MALIGNANCY. Stem Cells and Leukemia; V. Bebeshko et al.- Telomere and Stem Cell Biology in Chronic Myeloid Leukemia; S. Balabanov et al.- Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules - Enemies or Friends; B. Seliger.-The RUNXI Transcription Factor: A Gatekeeper in Acute Leukemia; C. Stocking et al.- IV. CELL PROCESSING, EXPANSION AND GENETIC MODIFICATION. Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population; N.M. Bilko et al.- Animal Hybrids and Stem Cells Their Use in Biotechnology and Clinical Practice; L.P. Djakonov.- Cryopreservation of Stem Cells; V.I. Grischenko et al.- The M813 Retrovirus Belongs to a Unique Interference Group and is highly Fusogenic; V. Prassolov.- Reconstructing an Anti-TumorImmune Repertoire for Targeted AML Therapy; M. Theobald.- V. CLINICAL HAEMATOPOIETIC STEM CELL TRANSPLANTATION. Experience of Kyiv Center of Stem Cell Transplantation; V.I. Khomenko.- Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors; A.R. Zander et al.-