As dogmas in stem cell research are losing their impact and recent findings regarding the use and cultivation of stem cells and tissue transplantation have opened up new therapeutic avenues, this Ernst Schering Research Foundation Workshop was initiated to highlight current and future approaches in this field. The only stem cells that have been used clinically for a long time is the hematopoietic stem cell as a source for bone marrow transplantation. Recent findings now indicate that hematopoietic stem cells, under certain conditions, are able to differentiate into endothelial, neural or muscle cells, providing exciting new therapeutic possibilities. They represent a future source for tissue engineering replacing defective cells or tissues and allowing diseased organs to regain their functions. Both reconstitution techniques are paving the way for the development of new therapeutic strategies, giving hope of being able to cure and not only treat patients.

Inhalt

1 Bone Marrow Reconstitution.- 2 Neuronal Stem Cells and Adult Neurogenesis.- 3 Tissue Engineering by Cell Transplantation.- 4 Myocardial Tissue Engineering.- 5 Cellular Transplantation for the Treatment of Heart Failure.- 6 A Truly New Approach for Tissue Engineering: The LOEX Self-Assembly Technique.- 7 Flat Membrane Bioreactor for the Replacement of Liver Functions.- 8 Tissue Engineering of Genitourinary Organs.