Summarizes cutting-edge findings on virulence factors, mechanisms of protection and therapeutic approaches

Equips readers with a fundamental tool for working on Staphylococcus aureus

Offers an invaluable source of information for a broad audience ranging from clinicians to academic researchers and applied scientists

Autorentext
Fabio BagnoliGSK Vaccines, Siena, Italye-mail: fabio.x.bagnoli@gsk.com
Rino RappuoliGSK Vaccines, Siena, Italye-mail: rino.r.rappuoli@gsk.com
Guido GrandiUniversity of Trento, Povo, Italye-mail: guido.grandi@unitn.it

Zusammenfassung

This volume offers a comprehensive overview of basic and applied aspects of Staphylococcus aureus, which is one of the most important human pathogens. It includes sixteen chapters that address the microbiology and immunology of S. aureus, the pathology of its key manifestations, and the current standard of care. Further, it reviews cutting-edge advances in alternative therapeutic and prophylactic approaches to antibiotics.

All chapters were written by respected experts in the field presenting recent findings on a diverse range of aspects, they are nonetheless interlinked. As such, the book is a must-read for all researchers, clinicians and technicians engaged in basic or applied science work involving S. aureus.

Inhalt

Clinical microbiology, transmission and carriage of Staphylococcus aureus.- Worldwide Epidemiology and antibiotic resistance of Staphylococcus aureus.- Structure and function of surface polysaccharides of Staphylococcus aureus.- Structure and function of surface proteins of Staphylococcus aureus.- Staphylococcus aureus pore-forming toxins.-Regulation of Staphylococcus aureus genes.- Staphylococcus aureus-associated Skin and Soft Tissue Infections.- Staphylococcus aureus-associated Musculoskeletal Infections.- Bacteremia, Sepsis, and Infective Endocarditis associated to Staphylococcus aureus.- Staphylococcus aureus as a zoonotic pathogen.- Antibiotic therapy of Staphylococcus aureus.- Innate immune responses against Staphylococcus aureus.- Adaptive immune responses against Staphylococcus aureus.- Immunevasion mechanisms of Staphylococcus aureus.- Vaccines and target populations for Staphylococcus aureus.- Bacteriophage and lysine therapy of Staphylococcus aureus.