In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.

Inhalt
Innovation and Experience.- Frontiers of Cancer Research: The Metastasis Challenge.- Vascular Endothelial Growth Factor: Basic Biology and Clinical Applications.- Proliferation and Cancer Metastasis from the Clinical Point of View.- Gastrointestinal Cancer and the Lymphatic System: Patterns of Micrometastasis and Lymphatic Mapping with Clinical Outcome.- Redefined Lymphatic Anatomy of the Breast with Clinical Implications.- Should Axillary Lymph Node Dissection be Done for Breast Cancer?.- Tumor Microenvironment and Proliferation.- Overview of Tumor Cells and the Microenvironment.- Lymphangiogenesis and Angiogenesis.- Heme/Lymphvasculogenesis, Hem/Lymphangiogenesis, Hem/Lymphangiotumorigenesis, and Tumor Hem/Lymphangiogenesis: Need for a Terminology Adjustment.- Tumor Lymphangiogenesis: What We Know and Don't Know.- Diagnostic Imaging of Cancer.- Molecular Imaging of Cancer: Receptors, Angiogenesis, and Gene Expression.- MRI and Ultrasound Imaging of Lymph Nodes.- Molecular Imaging of the Sentinel Lymph Node via Lymphoseek.- Lymphatic Disorders in Patients with Cancer.- 3D-CT Lymphography for Mapping Metastatic Breast Sentinel Node and Axillary Nodes.- Molecular Imaging of Neuroendocrine Cancer by Fusion SPET/CT.- Functional Molecular Imaging of Prostate Cancer Lymph Node Metastases: Adenovirus-Mediated Lymph Node Detection.- Therapeutic Targeting of the Lymphovascular System.- Therapeutic Targeting of the Lymphovascular System in Cancer: Promise and Challenge.- Comparison of Liposomal and Aqueous Blue Dye in Visualization of Lymph Nodes Prior to Lymphadenectomy.- Molecular Mechanisms of Metastasis.- The Role of Lymphangiogenesis in Regional Lymph Node Metastasis: Animal Models.- Sentinel Lymph Node Chemokine Microenvironment Modulated by Melanoma Metastasis.- Circulating and Disseminated Tumor Cells from Solid TumorsResearch and Clinical Aspects.- Head and Neck Cancer: An Example for the Role of Chemokine Receptors in Tumor Progression and Metastasis.- Tumor and Lymph Node Lymphangiogenesis.- Treg, Chemokines, and Other Small Molecules: Role in Metastasis and Its Prevention.- Molecular Targeted Therapy Against Growth Factor Receptors, Signaling Pathways and Angiogenesis as Therapeutic Targets.- Molecular Targeting of Lymphangiogenesis and Tumor Metastasis.- Combined Targeting of EGFR and Angiogenesis in Aerodigestive Carcinomas.- Targeting Signaling Pathways in Cancer Therapy.- Impact of Nodal Status and Tumor Burden in Sentinel Nodes on the Clinical Outcome.- Micrometastasis of Melanoma to Sentinel Lymph Nodes.- Sentinel Lymph Node Micrometastases in Breast Cancer: Prognostic Relevance and Therapeutic Implications.- Micrometastasis of Genitourinary Cancer to Sentinel Lymph Nodes.- Sentinel Lymph Node Mapping in Colorectal Cancer.- Application of Cancer Biology in Cancer Staging and Predicting Clinical Outcome.- Immune Responses in the Draining Lymph Nodes Against Cancer: Implication for Immunotherapy.- Role of Lymph Nodes in Immunotherapy of Malignant Tumors.- Tumor-Related Immune Modulation of the Regional Lymph Nodes.- Reversal of Immune Suppression in Sentinel Lymph Nodes.- Vaccine-Primed Lymph Node Cells in the Adoptive Immunotherapy of Cancer: Presence of Host Immune Suppression Induced by Established Cancer.- The Role of Stem Cells in Cancer Metastasis.- Cancer Stem Cells in Metastatic Melanoma.- Implications of Cancer Stem Cells for Tumor Metastasis.- Prostate Cancer Stem Cells and Their Involvement in Metastasis.- Genomic Signatures of Cancer: Basis for Selective Adjuvant Therapy.- Estrogen Receptor-Positive BreastCancer: Traditional Prognostics, Molecular Pathology: A New Breast Cancer Taxonomy and 21st Century Personalized Prognostic and Predictive Assays.- Molecular Signatures in Melanoma Progression.- Promising New Treatments for Solid Tumors.- Targeted Therapy for Breast Cancer: A Focus on HER2/neu and Antiangiogenic Therapy.- Advances in the Treatment of Colorectal Cancer: Targeting Receptors of Disease.- Developments in the Management of Genitourinary Malignancies: Prostate Cancer and Renal Cell Carcinoma.- Advances in the Treatment of Lung Cancer.- Recent Advances in the Treatment of Melanoma.- Pegylated Interferons in the Adjuvant Treatment of Melanoma.- Sorafenib, a Multikinase Inhibitor: Results from Clinical Trials in Melanoma Patients.- Targeting Immunological Synapse: New Horizons in Immunotherapy for Cancer.- Cutaneous Metastases of Melanoma: New Treatment Options.- Neoadjuvant Approaches in Melanoma.- Implications of Chemo/Biochemotherapy in the Treatment of Metastatic Melanoma.- Future Perspectives.- Future Perspectives for Cancer Metastasis: Unanswered Questions and Unquestioned Answers.