This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.

Autorentext

Dr. Xian-Cheng Jiang (PhD) is a Distinguished Professor at the State University of New York (SUNY). He is working at the Department of Cell Biology, SUNY Downstate Health Sciences University. His research focuses on lipid metabolism and metabolic diseases, such as atherosclerosis, metabolic syndrome, obesity and liver steatosis, particularly how sphingolipid metabolism influences plasma lipoprotein metabolism, cell membrane lipid composition and function, and the development of metabolic diseases.

Inhalt

Chapter 1: Sphingolipids and Cholesterol.- Chapter 2: Sphingolipids in adipose: kin or foe?.- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis.- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins.- Chapter 6: Sphingosine 1-phosphate metabolism and signaling.- Chapter 7: Sphingomyelin synthase family and phospholipase Cs.- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions.- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment.- Chapter 10: Sphingolipids and asthma.- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer.- Chapter 12: Drug development in the field of sphinogolipid metabolism.- Chapter 13: Rare diseases in glycosphingolipid metabolism.