This book constitutes the refereed proceedings of the 5th Ibero-American Congress on Smart Cities, ICSC-Cities 2022, held in Cuenca, Ecuador during November 28-30, 2022. The 17 full papers included in this book were carefully reviewed and selected from 116 submissions. They were organized in topical sections as follows: computational intelligence and urban informatics for smart cities, Internet of things, optimization, smart production, and smart public services and smart monitoring and communications