Bone is a sex hormone-dependent organ, which has important implications for current therapeutic strategies in the prevention and possible treatment of bone loss in the elderly. This book contains the proceedings of the Schering Workshop on "Sex Steroids and Bone." The various chapters by leading experts give and overall view of current knowledge on the control of bone hemostasis by sex steroids and new ideas on how this controlcould be exerted. It was also of particular concern to integrate a general survey of in vivo experimentation and histomorphometric evaluation of bone tissue. The organizers of the workshop and editors of this volume hope that it will contribute to a better understanding of the role of sex steroids in bone and thus pave the way for a better experimental approach instudying drug effects on bone with the ultimate goal of improving therapy in bone diseases.

Inhalt

1 View of a Clinician: Sex Steroids and Osteoporosis.- 2 The Anabolic Action of Estrogen on Rat Bone.- 3 Progesterone and Its Role in Bone Remodelling.- 4 The Effect of Sex Steroids on Calciotropic Hormones In Vivo.- 5 Effects of Estrogen on Growth Factors in Bone.- 6 Estrogens, Cytokines, and Bone Metabolism.- 7 Sex Steroids and Prostaglandins in Bone Metabolism.- 8 Animal Models for Osteoporosis.- 9 The Rat as an Animal Model of Postmenopausal Bone Loss.- 10 Histomorphometric Studies of Bone Changes in Ovariectomized Rats and Their Prevention by Estrogen Replacement.- 11 Biochemical Assessment of Bone Metabolism in Rodents.