Translational Medicine

Dieses Referenzwerk bietet einen vollständigen Überblick über die verschiedenen Phasen der Wirkstoffentwicklung und greift dabei auf einen translationalen Ansatz zurück.

Autorentext
Robert A. Meyers obtained his Ph.D. in Chemistry at the University of California at Los Angeles. He was a post-doctoral fellow at the California Institute of Technology and has more than 17 patents, 50 technical papers and 12 books to his name. As Editor-in-Chief he conceived and edited several ambitious multivolume reference works, e.g. the Encyclopedia of Analytical Chemistry (Wiley), the Encyclopedia of Molecular Biology and Molecular Medicine (Wiley-VCH) and the Encyclopedia of Physical Science and Technology (Academic Press).

Zusammenfassung
This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Inhalt
Cancer Biomarkers
Inflammatory and Immunological Biomarkers
Metabolic phenotyping
Neurological Biomarkers
Protein Biomarkers
Translation of Biomarkers into Clinical Practice
Antibody Molecules, Genetic Engineering of
Genetic Engineering of Hemoglobin
Genetic Engineering of Vaccines
Pharmacology and Emerging Clinical Application of RNA
Plant-based Expression of Biopharmaceuticals
RNAi Gene Therapy to Combat HIV-1 Infection
RNAi to Treat Chronic Hepatitis B Virus Infection
RNAi to Treat Chronic Hepatitis C Infection
Sex Hormones (Male): Analogs and Antagonists
Somatic Gene Therapy
Vaccine Research and Development
Biotransformations of Drugs and Chemicals
Drug Bioavailability, Distribution and Clearance Prediction
Microbial Metagenomics and Drug Bioavailability, Toxicity and Efficacy
Pharmacokinetics and Pharmacodynamics of Biotech Drugs
Liposome Gene Transfection
Nanometer-scale Polymers for Enhancing Drug Delivery
Physical Pharmacy and Biopharmaceutics
Preclinical Form & Formulation for Drug Discovery
Targeting and Intracellular Delivery of Drugs
Transporters in Translational Medicine
Vaccination, Genetic
Vector Targeting in Gene Therapy
Virus-free Gene Transfer systems in Somatic Gene Therapy
Alzheimer's Disease Drug Development
Antisense Oligonucleotides as Potential Drugs
Artificial Organs and Tissues for Drug Discovery
Biomarkers in oncology drug development
Exploiting Model Organisms for Disease Intervention
Generic versions of therapeutic proteins (Biosimilars) Approaches and Problems
HIV Prevention Pharmaceuticals Development (pre-exposure prophylaxis (PrEP). )
Natural Products Based Drug Discovery
Nucleic Acid Metabolism and Drug Discovery
Organic Chemistry in Drug Discovery
Pharmacogenomics and Drug Design
Predictive Drug Safety
Receptor Targets in Drug Discovery
Structure-based Drug Design and NMR-based Screening
Therapeutic Compounds in Nature as Leads for New Pharmaceuticals
Triacylglycerol Storage and Mobilization, Storage of
Tuberculosis Drug Development
Combinations of Agents for the Diagnosis, Therapeutic or Prognosis Testing
Experimental Design, Conduct, and Analysis of Clinical Trials
Novel Therapeutics for Targeting Pain
Analysis and Pharmaceutical Quality
Bioprocess Engineering
Pharmaceutical Process Chemistry
Production and Commercialization of new Biotechnology Based Pharmaceuticals
Xenotransplantation in Pharmaceutical Biotechnology
Antibody-enabled small-molecule drug discovery
Antimalarial Drug Discovery
Discovery and Development of Small Molecule Cancer Drugs
High-throughput behavioral profiling to discover and Characterize Psychotropic Drugs
Hit-to-Lead Medicinal Chemistry