Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.

Inhalt

1. Towards Synthetic Gene Circuits with Enhancers: Biology's Multi-input Integrators. - 2. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways. - 3. Evolutionary Engineering for Industrial Microbiology. - 4. Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches. - 5. Synthetic Biology Triggers New Era of Antibiotics Development. - 6. Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis. - 7. Systems Analysis of Microbial Adaptations to Simultaneous Stresses. - 8. Metabolic Reprogramming under Microaerobic and Anaerobic Conditions in Bacteria. - 9. Tunable Promoters in Synthetic and Systems Biology. - 10. Analysis of Corynebacterium glutamicum Promoters and Their Applications. - **11. Production of Fumaric Acid by Fermentation. - 12. Metabolic Engineering of Microorganisms for Vitamin C Production. - 13. Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum. - 14. Microbial Metabolic Engineering for L-threonine Production. - 15. The Production of Coenzyme Q10 in Microorganisms. - 16. Genetic Modification and Bioprocess Optimization for S-adenosyl-L-methionine biosynthesis. - 17. Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-based Products. - 18. Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei. - 19. Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis.