This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects. It details recent advances in work on the genetic disorders of cardiac troponin and ryanodine receptor proteins. Many color figures illustrate the three-dimensional structures of the proteins involved in the muscle functions. The book will help readers understand characteristic features of the regulatory mechanisms of striated muscle contraction and their disorders at the molecular level.

Zusammenfassung

Troponin is a central subject in biochemical, biophysical, and physiological research. The discovery of this protein initiated a new era in research into the molecular biology of the regulation of contraction in striated muscle. This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects. It details recent advances in work on the genetic disorders of cardiac troponin and ryanodine receptor proteins. Many color figures illustrate the three-dimensional structures of the proteins involved in the muscle functions. The book will help readers understand characteristic features of the regulatory mechanisms of striated muscle contraction and their disorders at the molecular level.

Inhalt
Historical Aspects.- Biological Actions of Calcium.- Professor Ebashi's Journey Toward the Discovery of Troponin: A Personal Recollection.- Highlights of the History of Calcium Regulation of Striated Muscle.- Regulation by Troponin and Tropomyosin.- Troponin: Structure, Function and Dysfunction.- From the Crystal Structure of Troponin to the Mechanism of Calcium Regulation of Muscle Contraction.- Ca Ion and the Troponin Switch.- Disposition and Dynamics: Interdomain Orientations in Troponin.- Structural Basis for Calcium-Regulated Relaxation of Striated Muscles at Interaction Sites of Troponin with Actin and Tropomyosin.- Tropomyosin: Regulator of Actin Filaments.- Tropomyosin and Troponin Cooperativity on the Thin Filament.- Conformational Changes in Reconstituted Skeletal Muscle Thin Filaments Observed by Fluorescence Spectroscopy.- Calcium Structural Transition of Troponin in the Complexes, on the Thin Filament, and in Muscle Fibres, as Studied By Site-Directed Spin-Labelling EPR.- Crystal Structures of Tropomyosin: Flexible Coiled-Coil.- C. Elegans Model for Studying Tropomyosin and Troponin Regulations of Muscle Contraction and Animal Behavior.- Structural and Functional Analysis of Troponins from Scallop Striated and Human Cardiac Muscles.- Regulation in Cardiac Muscle and Disorders.- Cooperativity in the Regulation of Force and the Kinetics of Force Development in Heart and Skeletal Muscles.- Heart Failure, Ischemia/Reperfusion Injury and Cardiac Troponin.- Troponin Mutations in Cardiomyopathies.- Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in Cardiac Troponin T.- Cardiac Troponin Levels as a Preferable Biomarker of Myocardial Cell Degradation.- Regulation by Myosin.- Regulation by Myosin: How Calcium Regulates Some Myosins, Past andPresent.- Calcium Inhibition of Physarum Myosin as Examined by the Recombinant Heavy Mero-Myosin.- Excitation-Contraction Coupling and Disorder.- Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum.- Dysregulation of the Gain of CICR Through Ryanodine Receptor1 (RyR1): The Putative Mechanism Underlying Malignant Hyperthermia.- Ion Pumping by Calcium ATPase of Sarcoplasmic Reticulum.- Regulation of Cell Functions by Ca2+ Oscillation.- Molecular Mechanisms of Muscle Contraction.- Evidence About the Structural Behaviour of Myosin Crossbridges During Muscle Contraction.- Structural Alterations of Thin Actin Filaments in Muscle Contraction by Synchrotron X-ray Fiber Diffraction.- Regulation of Muscle Contraction by Ca2+ and ADP: Focusing on the0 Auto-Oscillation (SPOC).- Muscle Contraction Mechanism Based on Actin Filament Rotation.- On the Walking Mechanism of Linear Molecular Motors.- Modeling of the F-Actin Structure.