This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders.

Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on.

This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area.

This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.

Autorentext
Editors:
Nariyoshi Shinomiya
Department of Integrative Physiology and BioNano Medicine, National Defense Medical College, Tokorozawa, Japan
Hiroaki KataokaDepartment of Pathology, University of Miyazaki, Miyazaki, Japan

Qian XieDepartment of Biomedical Sciences, East Tennessee State University, Johnson City,
TN, USA

Inhalt

1. Regulation of microRNA expression by growth factors.- 2. TGF-b signaling and epithelial mesenchymal transition.- 3. Molecular designing of small molecule inhibitor for apoptotic pathways.- 4. Using genetically engineered mouse models to study Wnt signaling in bone development and disease.- 5. Glucose signaling and glycolysis.- 6. The interplay of tumor suppressor p53 with hypoxia-inducible factor-1 (HIF-1) at the crossroad between hypoxia-mediated cell survival and death.- 7. Role of G protein-coupled receptor signaling on the proliferation and differentiation of multipotent stem cells.- 8. Met-KO and carcinogenesis
2. Clinical impact of MET pathway in cancer.- 10. Pericellular proteolytic activation of growth factors.