We are especially grateful to Dr. Philip Corfman and his colleagues of the Population and Reproduction Grants Branch of NICHD for making this Conference possible. The format of this volume follows in general the order in which the papers were presented during the Conference. The Conference was divided into four sessions, each of which was presided over by a capable and distinguished scientist. Each of these chairmen, Drs. T. H. Hamilton, G. A. Puca, R. L. Vande Wiele and H. G. Williams-Ashman provided valuable discussion and for their services we are most appreciative. The Editors are indebted to Mr. Robert Colligan for his help in organizing and in redacting the manuscripts. A special commen­ dation is also extended to Ms. Mary Jane Fowler who cheerfully and efficiently typed this entire volume. Finally, we express thanks to the individual participants of the Conference for their cooperation and prompt submission of the manuscripts and to the Plenum Press for ensuring the rapid publica­ tion of this volume. Anthony R. Means, Ph.D. Bert W. O'Malley, M. D.

Inhalt

The Continuing Evolution of an Estrogen-Receptor Model.- Nuclear Receptor · Estrogen Complexes of Rat Uteri: Concentration-Time-Response Parameters.- Estrogen Receptor Transformation and Nuclear RNA Synthesis.- Estradiol Receptors: A New Evaluation.- The Interaction of Uterine Estrogen Receptors with DNA.- Estrogen Binding in the Rat and Human.- Studies on the Estrogen Receptor in Breast Cancer.- Studies on Androgen and Estrogen Uptake by Rat Hypothalamu.- Hormone - Receptor Interactions with the Genome of Eucaryotic Target Cells.- A Review of Current Research on the Binding and Mechanism of Action of Androgenic Steroids, Notably 5?-Dihydrotestosterone.- Androgen - Receptor Cycling in Prostate Cells.- Adenyl Cyclase and the Cyclic AMP Responsive Systems in the Uterus.- Affinity Labeling Steroids for Characterization of Steroid Binding Sites.- Mathematics of Hormone - Receptor Interaction.- I. Basic Principles.- Theory of Radioimmunoassays and Hormone - Receptor Interactions:.- II. Simulation of Antibody Divalency, Cooperativity and Allosteric Effects.- Theory of Hormone Receptor Interaction.- III. The Endocrine Target Cell as a Quantal Response Unit: A General Control Mechanism.- Autoradiographic Analysis of Gonadotropin Binding to Rat Ovarian Tissue Sections.- Interactions of LH and hCG with Testicular Gonadotropin Receptors.- Luteinizing Hormone Receptors in Luteinized Rat Ovaries.- Specific Interaction of 3H-FSH with Rat Testis Binding Sites.