Reasoning in terms of molecular recognition may be traced back to Emil Fischer, who practiced the art of chemistry at Humboldt University in Prussian Berlin a century ago. Today, it is clearly recognized that molecular recognition impacts and determines all life processes. It has become a key research field in both chemistry and biology and the emerging interface of what now is being called "chemical biology". The technological advances derived from this knowledge are particularly important, diverse, and directly evident in the pharmaceutical industry. Under the auspices of the Ernst Schering Research Foundation, a workshop held in Berlin in February 1998 addressed novel basic developments of potential relevance to drug research efforts. A balance of timely research topics in molecular recognition is presented in the lectures delivered by a multidisciplinary international panel of renowned scholars and documented in this volume.

Inhalt

Designing Transition Metal Complexes for Molecular Recognition in Synthetic Transformations; REDOR NMR of Biological Solids; Molecular and Dendritic Receptors for Small Biomolecules; Molecular Recognition of DNA by Ecteinascidin 743; New Tools for Drug Design Based on Protein Ligand Recognition Principles; Sequence-Specific Recognition of DNA and Control of Gene Expression; Combinatorial Nucleic Acid Libraries; Sequence Specific Recognition of Double Stranded DNA; Solid Phase Libraries of Glycopepetide Templates