Proteome research is a systematic approach to characterising the protein complement of a tissue or organism, and can be considered a complementary approach to the genome project. The proteome approach is attracting considerable interest also from pharmaceutical companies, and is already showing great potential in clinical applications.

Inhalt

1 Introduction to the Proteome.- 2 Two-Dimensional Electrophoresis: The State of the Art and Future Directions.- 3 Protein Identification in Proteome Projects.- 4 The Importance of Protein Co- and Post-Translational Modifications in Proteome Projects.- 5 Proteome Databases.- 6 Interfacing and Integrating Databases.- 7 Large-Scale Comparative Protein Modelling.- 8 Clinical and Biomedical Applications of Proteomics.- 9 Biological Applications of Proteomics.- 10 Conclusions.