Progress in sequencing and characterizing the human genome has transformed cancer genetics both conceptually and methodologically. In Prostate Cancer: Biology, Genetics, and the New Therapeutics, leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer, as well as its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer, and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth, progression, and stromal-epithelial interaction has revealed many new possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differentiation therapies, and gene therapy.
Comprehensive and cutting-edge, Prostate Cancer: Biology, Genetics, and the New Therapeutics synthesizes all the major recent work that is not only rapidly unraveling the mysteries of prostate cancer, but also dramatically improving today's therapeutic approaches.

Klappentext

This book embraces the wide field of prostate cancer genetics, biology, and therapy. It seems most appropriate to dedicate it to Donald S. Coffey, PhD, whose research vision is an inspiration to his colleagues and friends. Unraveling the secrets of prostate cancer is an intricate and sometimes frustrating process involving many researchers and many institutions. No one has seen through to the end of this road, and the list of researchers who have contributed to our understanding of the disease processes of prostate cancer is already a long one. But Donald Coffey stands out in his personal qualities as surely as in his roles as teacher and researcher. In the dedicatory article that begins this volume, Dr. Ward has spoken for all of us about Don Coffey's unique determination to build the road to defeat prostate cancer. This book is divided into three sections: Cancer Genetics, Cancer Biology, and Cancer Therapeutics. These sections, like the skill and knowledge of the contributors, overlap in many dimensions. The divisions between sections are somewhat arbitrary and have been made expressly for the convenience of the reader. The reader will find chapters in each section that illuminate aspects ofthe genetics, biology, and therapy of prostate cancer. Nothing better illustrates the breadth of the research being conducted today by these distinguished groups, who truly understand and appreciate the power of multi­ disciplinary and translational approaches to deciphering the intricacy of the object of this research.

Inhalt

Part I. Introduction. Building the Road to Defeat Prostate Cancer: A Dedication to Donald S. Coffey, W. Steven Ward. Part II. Cancer Genetics. Hereditary Prostate Cancer, William B. Isaacs, Jianfeng Xu, and Patrick C. Walsh. AR Gene Alterations in Prostate Cancer Progression, Tapio Visakorpi. Lethal Metastatic Human Prostate Cancer: Autopsy Studies and Characteristics of Metastases, G. Steven Bova, Kirk M. Chan-Tack, and William W. LeCates. Tumor Suppressor Genes in Prostate Cancer, Robert Bookstein. Androgen Receptor Polymorphisms and Prostate Cancer Risk, Phillip G. Febbo and Philip W. Kantoff. The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease, Ronald K. Ross, Juergen K. V. Reichardt, Sue Ann Ingles, and Gerhard A. Coetzee. Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques, Junqi Qian and Robert B. Jenkins. Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN), Paul H. Duray, David K. Ornstein, Cathy D. Vocke, Stephen M. Hewitt, Kristina A. Cole, John W. Gillespie, Chad R. Englert, Emanuel F. Petricoin, David B. Krizman, W. Marston Linehan, and Michael R. Emmert-Buck. Xenograft Models and the Molecular Biology of Human Prostate Cancer, Robert E. Reiter and Charles L. Sawyers. Comprehensive Analyses of Prostate Gene Expression, Peter S. Nelson. Part III. Cancer Biology. The Role of Nuclear Matrix and Cytoskeleton in Cancer, Robert H. Getzenberg. The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis, Jer-Tsong Hsieh. Ligand Dependent and Independent Activation of Androgen Receptor, Gloria R. Mora and Donald J. Tindall. Tyrosine Kinases and Cellular Signaling in Prostate Cancer, Hsing-Jien Kung, Clifford G. Tepper, and Ralph W. deVere White. Molecular Pathways that Underlie Prostate Cancer Progression: The Role of Caveolin-1, Timothy C. Thompson, Terry L. Timme, Likun Li, Chengzen Ren, Alexi Goltsov, Salahaldin Tahir, and Guang Yang. Angiogenesis and Prostate Cancer, Ingrid B. J. K. Joseph and John T. Isaacs. Prostate Specific Membrane Antigen, Denise S. O'Keefe, Dean J. Bacich, and Warren W. D. Heston. Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen- and Chemo-Sensitivity in Prostate Cancer, Martin E. Gleave, Hideaki Miyake, Colleen Nelson, Paul Rennie, and Simon Leung. Stromal-Epithelial Interaction: From Bench to Bedside, Leland W. K. Chung and Haiyen E. Zhau. Part IV. Cancer Therapeutics. Chemoprevention of Prostate Cancer, James D. Brooks and William G. Nelson. Anatomic Radical Retropubic Prostatectomy for Prostate Cancer, Misop Han and Alan W. Partin. Radiation Therapy as Applied to Prostate Cancer: Clinical, Technical, and Biologic Considerations, Naren R. Ramakrishna and Theodore L. DeWeese. Prostate Cancer Chemotherapy: Closing Out a Century and Opening a New One, Jeffrey M. Kamradt and Kenneth J. Pienta. The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer, Joel B. Nelson. Development of Dendritic Cell-Based Prostate Cancer Vaccine, Benjamin A. Tjoa and Gerald P. Murphy. Antiprogression Agents for Prostate Cancer, Hadley M. Wood and Michael A. Carducci. Human Gene Therapy for Urological Oncology, Fernando Ferrer, Jonathan W. Simons, and Ronald Rodriguez. Chemoprevention Trials for Prostate Cancer, Peter Greenwald and Ronald Lieberman. Index.