This unique book presents an up-to-date discussion of clinical disorders of the pituitary gland in children with specific emphasis on state-of-the-art diagnostic and treatment modalities, highlighting the newest scientific advances in genomics and molecular biology that clinician-scientists caring for children need to know. Chapters focus on the current knowledge base in genomics, pathophysiology, diagnosis, and medical and surgical management, organized into thematic sections. Part I discusses embryologic and genetic disorders, including genomics and congenital disorders of the pituitary. Part II presents acquired pituitary disorders, such as prolactinomas, Cushing's Disease, and both hormone secreting and non-secreting pituitary tumors. Subsequent sections cover posterior pituitary disorders, such as diabetes insipidus, functional hormone deficiencies of the hypothalamic-pituitary axis, including delayed puberty and pubertal disorders and growth hormone disorders, neuro-opthalmic disease, CNS radiation, childhood cancer treatment and traumatic brain injury. Authoritative and comprehensive, Pituitary Disorders of Childhood will serve as a precise guide for clinical endocrinologists and will guide future investigation into translational and clinical research on the pediatric pituitary.

Autorentext
Brenda Kohn, MD, Associate Professor, Department of Pediatrics, Director, Division of Pediatric Endocrinology and Diabetes, NYU Langone Medical Center, New York, NY, USA

Inhalt

Part I. Embryologic and Genetic Disorders of the Pituitary Gland.- Genomics.- Genetics of Hypopituitarism.- Part II. Acquired Pituitary Disorders: Pituitary Tumors and Nonpituitary Sellar Masses.- Adamantinomatous Craniopharyngioma: Genomics, Radiologic Findings, Clinical, Prognosis.- Prolactinomas.- Cushing's Disease: Diagnosis and Treatment.- Surgery for Cushing's Disease.- Gigantism and Acromegaly.- TSH Secreting Pituitary Adenomas.- Molecular Predictors of Clinical Behavior in Pituitary Adenohypophysial Tumors.- Nonpituitary Sellar Masses and Infiltrative Disorders.- Part III. Posterior Pituitary Disorders.- Posterior Pituitary Disorders: Anatomy and Physiology; Central Diabetes Insipidus (CDI); Syndrome of Inappropriate Anti-diuretic Hormone (SIADH).- Part IV. Functional Hypothalamic-Pituitary Hormone Deficiencies.- Congenital Hypogonadotropic Hypogonadism (Isolated GnRH Deficiency).- Genetics of Delayed Puberty.- Hypothalamic Amenorrhea.- Part V. Neuro-opthalmic Diseases.- Neuro-ophthalmic Diseases and Endocrinologic Function.- Part VI. CNS Radiation.- CNS Radiation of Childhood CNS Tumors.- Part VII. Childhood Cancer Treatment.- Hypothalamic-Pituitary Dysfunction as a Late-Effect of Childhood Cancer, Brain Tumors and their Treatments.- Part VIII. Traumatic Brain Injury.- Pituitary Response to Traumatic Brain Injury.