This textbook emphasizes the pediatric aspects of Inflammatory Bowel Disease (IBD). It covers the diagnostic approach, special nutrition, growth, bone density as well as psychosocial considerations that are different and may not exist in adults. Chapters discuss IBD genetics, immunology, epidemiology, pharmacogenomics, diagnosis (clinical, laboratory, radiologic, histologic and endoscopic), nutritional and growth aspects, psychosocial issues, extraintestinal manifestations, and management (divided into medical, nutritional and surgical therapy), with special emphasis on new biologic therapeutics. In addition, several short chapters address issues of perianal IBD, cancer surveillance, alternative therapy and transition to adult care. The book features many visual aides, including tables, figures, schemes, algorithms, as well as endoscopy and surgery images.

Zusammenfassung
Pediatric Inflammatory Bowel Diseases (IBD) are the most common and most significant chronic disorders in Pediatric Gastroenterology. The onset of Crohn disease and ulcerative colitis in the first two decades of life presents a number of diagnostic and therapeutic challenges that are unique to pediatric patients. Although the studies available for pediatric diagnosis have improved dramatically in the past three decades, the improvement in technology alone cannot account for the increased frequency of IBD recognized in early childhood. While therapy for older patients has improved dramatically with the use of immunomodulators and the development of exciting biologic strategies, rarely if ever have comprehensive studies of the pharmacokinetics, safety and efficacy of any of the IBD medications been performed in pediatric patients. A number of excellent medications are not available in liquid preparations that can be swallowed by children, and others, such as timed-release formulations, are developed for delivery to an adult gastrointestinal tract. It is unfortunate that the care we provide to children is often an extrapolation of what is known about and available for adults with IBD. Pediatric patients with IBD face a number of unique challenges. The onset of disease before puberty can be devastating. Growth failure is a particularly difficult problem with potentially permanent consequences. Much of the pediatric specific research has focused on the role of nutritional therapy to treat growth failure and induce remission.

Inhalt
Etiology and Pathogenesis.- Genetics of Inflammatory Bowel Diseases.- Gut Immunity and Inflammatory Bowel Disease.- Cytokines and Inflammatory Bowel Disease.- Epidemiology and Clinical Features.- Epidemiology of Pediatric Inflammatory Bowel Disease.- Early Onset Inflammatory Bowel Disease- Epidemiology and Clinical Features.- The Natural History of Pediatric Crohn Disease.- Natural History of Pediatric Ulcerative Colitis.- Natural History of Pediatric Indeterminate Colitis.- Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease.- Growth Impairment in Pediatric Inflammatory Bowel Disease.- Skeletal Health in Pediatric Inflammatory Bowel Disease.- Puberty and Pediatric-Onset Inflammatory Bowel Disease.- Classification of Pediatric Inflammatory Bowel Disease.- Diagnosis.- The History and Physical Exam in Pediatric Inflammatory Bowel Disease.- Differential Diagnosis of Pediatric Inflammatory Bowel Disease.- Laboratory Evaluation of Pediatric Inflammatory Bowel Disease.- Radiologic Evaluation of Pediatric Inflammatory Bowel Disease.- Endoscopic Modalities in Pediatric Inflammatory Bowel Disease.- The Pathology of Chronic Inflammatory Bowel Disease.- Video Capsule Endoscopy in Pediatric Inflammatory Bowel Disease.- Bone Health Assessment in Pediatric Inflammatory Bowel Disease.- Assessment of Growth and Nutritional Status in Pediatric Inflammatory Bowel Disease.- Medical Therapy.- Pharmacogenetics in Inflammatory Bowel Disease.- 5-Aminosalicylate Therapy.- Antibiotic Therapy.- Nutritional Therapy.- Probiotic Therapy.- Corticosteroid Therapy.- 6-Mercaptopurine Therapy.- Methotrexate Therapy.- Infliximab Therapy.- Biologic Therapies.- Treatment of Perianal Crohn Disease Fistulae.- Treatment of Fulminant Colitis.- Surgical Therapy.- Surgical Management ofCrohn's Disease.- Surgical Treatment of Ulcerative Colitis.- Pouchitis After Ileal Pouch-Anal Anastomosis.- Enteral Feeding Devices and Ostomies.- Research.- Clinical Indices for Pediatric Inflammatory Bowel Disease Research.- Clinical Trials (Clinical Perspective).- Clinical Trials (Industry Perspective).- Special Considerations.- Psychological Aspects of Pediatric Inflammatory Bowel Disease.- Measurement of Quality of Life in Pediatric Inflammatory Bowel Disease.- Irritable Bowel Syndrome and Functional Gastrointestinal Disorders in Pediatric Inflammatory Bowel Disease.- Inflammatory Bowel Disease in Pregnancy.- Malignant Tumors Arising in Inflammatory Bowel Disease.- Quality Improvement in Inflammatory Bowel Disease.- Advocacy for Pediatric Patients with Inflammatory Bowel Disease.- Legislative Advocacy.- Transition from Pediatric to Adult Care.