This book constitutes the refereed post-conference proceedings the 14th TPC Technology Conference on Performance Evaluation and Benchmarking, TPCTC 2022, which was held in Sydney, NSW, Australia, on September 5, 2022. The 5 revised full papers presented were carefully selected from 12 submissions. The conference focuses on Pick and Mix Isolation Levels; Benchmarking considerations for Trustworthy and Responsible AI (Panel); Preliminary Scaling Characterization with TPCx-AI and New Initiatives.