Genome sequencing and analysis have yielded a rich harvest of fundamental information about pathogenesis and have raised significant new possibilities for effective therapeutic intervention. In Pathogen Genomics: Impact on Human Health, a panel of leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to infectious disease prevention, diagnosis, and treatment. The authors' cross-disciplinary approach-with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa-reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA microarrays and the impact of genome sequencing comparisons to the discovery and choices of novel drug targets. The result is a better understanding of how these tools can be used to explore the fundamentals of microbial pathogenesis, as well as how pathogens interact with each other and with their host environments.
Broad-ranging and illuminating, Pathogen Genomics: Impact on Human Health offers today's infectious disease specialists an authoritative analysis of the new genomic technologies and their productive application to drug discovery, vaccine development, and diagnostics.

Klappentext

Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment.

Inhalt

Part I. Viruses Antiviral Drug Target Discovery with DNA Microarrays Klaus Früh and Peter Ghazal Chipping Away at HIV Pathogenesis Steffney Elise Rought, Roman Sasik, Davey Mitchell Smith, and Jacques Corbeil Microarray Analysis of Human Papillomavirus Pathogenesis Yijan Elaine Chang and Laimonis A. Laimins Ribozymes as Gene Therapeutic Agents for HIV/AIDS: A Potential Paradigm Shift Gregory C. Fanning, Janet L. Macpherson, and Geoff Symonds Part II. Bacteria Genomics and New Technologies Applied to Antibacterial Drug Discovery Donald T. Moir Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines Marcel A. Behr and Stephen V. Gordon Bacterial 'Genes-to-Screens' in the Post-Genomic Era Michael J. Pucci, John F. Barrett, and Thomas J. Dougherty DNA Microarray Expression Analysis in Antibacterial Drug Discovery Brian J. Morrow and Karen Joy Shaw The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens Richard V. Goering Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development Alireza Shamaei-Tousi and Sven Bergström Part III. Fungi Antifungal Target Discovery and Validation: Lessons from Saccharomyces cerevisiae Beth DiDomenico and Scott S. Walker Antifungal Drug Discovery: Old Drugs, New Tools Marianne D. De Backer, Walter H. M. L. Luyten, and Hugo F. Vanden Bossche Cryptococcus neoformans: A Molecular Model for the Study of Fungal Pathogenesis and Drug Discovery in the Genomic Era Jennifer K. Lodge and John R. Perfect Antifungal Target Selection in Aspergillus nidulans: Using Bioinformatics to Make the Difference Rosanna Pena-Muralla, Patricia Ayoubi, Marcia Graminha, Nilce M. Martinez-Rossi, Antonio Rossi, and Rolf A. Prade Functional Genomics ofHistoplasma capsulatum: Dimorphism and Virulence Glenmore Shearer, Jr. Gene Finding in Coccidioides immitis: Searching for Immunogenic Proteins Theo N. Kirkland and Garry T. Cole Part IV. Protozoa Toxoplasma gondii: A Model for Evolutionary Genomics and Chemotherapy Jessica C. Kissinger, Michael J. Crawford, David S. Roos, and James W. Ajioka The Molecular Biology and Pathogenicity of Entamoeba histolytica Barbara J. Mann and Brendan J. Loftus Index