This two-volume set LNICST 631 & 632 constitutes the proceedings of the Third Pan-African Conference on Pan-African Intelligence and Smart Systems, PAAISS 2024, which was held in Durban, South Africa, during December 4-6, 2024. The 39 full papers presented in this volume were carefully reviewed and selected from 103 submissions. They are organized according to the following topics: Part-I : Artificial Intelligence in Medicine; Smart Systems Enabling Technologies; and Artificial Intelligence-Enabled Communication Systems. Part-II : Artificial Intelligence Theory and Methods; Artificial Intelligence and Smart Systems; Remote sensing and Artificial Intelligence.