It can honestly be said that the scope and magnitude of this meeting surpassed initial expectations with respect to the number and quality of the papers presented. Our group has grown since we last met in Dortmund in 1971. This is a good indication that a spiraling of our interests has taken place with the effects of the initial good work felt, not just in one corner of the globe, but in all four. With such a start, it was only appropriate that an international society was formed at the meeting to further coordinate our mutual undertaking. Henceforth it shall be known as the International Society of Oxygen Transport to Tissue. A final note of acknowledgement should be made to those who were in the supporting cast, not only in making the meeting in Charleston and Clemson a success, but also in the compiling of this book. Gratitude is due to Dr. Daniel H. Hunt for his efforts, the end product of which you have in your hands. Considerable service was rendered by Mr. Robert J. Adams, Mr. Buddy Bell and Mr. Nathan Kaufman during the symposium itself. Much typing, organizing and record keeping was done by our lovely secretaries, Laura B. Grove, Muff Graham and Kaye Y. Zook.

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of Volume 2 (Volume 37B).- Session III - The Pharmacology of Improving Oxygen Transport to Tissue.- Blood Cell Aggregation and Pulmonary Embolism.- Sludged Blood, Human Disease and Chemotherapy.- Intravascular Aggregation of Blood Cells and Tissue Metabolic Defects.- Anti-Adhesive Drugs and Tissue Oxygenation.- Oxygen Transport and Tissue Oxygenation During Hemodilution with Dextran.- Platelet Aggregates Induced by Red Blood Cell Injury.- Recent Advances in the Preparation and Use of Perfluorodecalin Emulsions for Tissue Perfusion.- Pharmacological Stimulation of Red Blood Cell Metabolism for High Altitude Preadaptation.- Catecholamine Metabolism and Digital Circulation after Histamine and Its Analogue.- Augmentation of Tissue Oxygen by Dimethyl Sulfoxide and Hydrogen Peroxide.- In Vitro Respiration of Ischemic Skin from Amputated Human Legs.- Altering Diffusion Rates.- Discussion of Session III.- Session IV - Mathematical Studies of Tissue Oxygenation Part A.- Mathematical Considerations for Oxygen Transport to Tissue: Introductory Paper.- Geometric Considerations in Modeling Oxygen Transport Processes in Tissue.- Capillary-Tissue Exchange Kinetics: Diffusional Interactions between Adjacent Capillaries.- Computer Calculation for Tissue Oxygenation and the Meaningful Presentation of the Results.- Stochastic versus Deterministic Models of Oxygen Transport in the Tissue.- Existing Anatomical Parameters and the Need for Further Determinations for Various Tissue Structures.- Mathematical Analysis of Oxygen Transport to Tissue in the Human.- A Mathematical Model of the Unsteady Transport of Oxygen to Tissues in the Microcirculation.- Simplifying the Description of Tissue Oxygenation.- A Simplified Model of the Oxygen Supply Function of Capillary Blood Flow.- Oxygen Transport in the Human Brain - Analytical Solutions.- Calculation of Concentration Profiles of Excess Acid in Human Brain Tissue During Conditions of Partial Anoxia.- Simulating Myocardium Oxygen Dynamics.- Numerical Solutions of Blood Flow in the Entrance of a Tube.- Discussion of Session IV - Part A.- Session IV - Mathematical Studies of Tissue Oxygenation Part B.- Distributed Model Solution Techniques for Capillary-Tissue Systems.- Heterogeneous Models of Oxygen Transport in Tissue Slices.- Mathematical Modelling of the Cornea and an Experimental Application.- Instrumentation and Control Techniques for Dynamic Response Experiments in Living Tissue.- Oxygen Transport in Skeletal Muscle: How Many Blood Capillaries Surround Each Fibre?.- Filtering and Prediction of Blood Flow and Oxygen Consumption for Patient Monitoring.- Computer Analysis of Automatically Recorded Oxygen Dissociation Curves.- A Polygonal Approximation for Unsteady State Diffusion of Oxygen into Hemoglobin Solutions.- Gaseous Transport in Hemoglobin Solutions.- Mechanochemical Pumping as an Adjunct to Diffusion in Oxygen Transport.- An Analysis of the Competitive Diffusion of O2 and Co through Hemoglobin Solutions.- Oxygen Mass Transfer Rates in Intact Red Blood Cells.- Effect of Carbonic Anhydrase on the Facilitated Diffusion of CO2 through Bicarbonate Solutions.- Modeling the Coronary Circulation: Implications in the Pathogenesis of Sudden Death.- Discussion of Session IV - Part B.- Session V - Oxygen Transport Problems in Neonatology.- Subsession: Placental Oxygen Transfer.- Experimental and Theoretical Investigations of Oxygen Transport Problems in Fetal Systems: Introductory Paper.- Microphotometry for Determining the Reaction Rate of O2 and CO with Red Blood Cells in the Chorioallantoic Capillary.- Mathematical Analysis of Combined Placental-Fetal Oxygen Transport.- Placental Function and Oxygenation in the Fetus.- Morphological Determinants in O2-Transfer across the Human and Rhesus Hemochorial Placenta.- Umbilical and Uterine Venous PO2 in Different Species During Late Gestation and Parturition.- Threshold Values of Oxygen Deficiency-Leading to Cardiovascular and Brain Pathological Changes in Term Monkey Fetuses.- Placental Oxygen Gradients Due to Diffusion and Chemical Reaction.- Experimental Models for in vivo and in vitro Investigations on Placental Hemodynamics and Oxygen Supply to the Fetus.- Material Alkalosis and Fetal Oxygenation.- Hemoglobin Concentration Overestimates Oxygen Carrying Capacity During Favic Crises.- Discussion of Subsession: Placental Oxygen Transfer.- Subsession: Oxygen Monitoring.- Measurement of Oxygen in the Newborn.- Oxygen Monitoring of Newborns by Skin Electrodes. Correlation between Arterial and Cutaneously Determined PO2.- A Unique Electrode Catheter for Continuous Monitoring of Arterial Blood Oxygen Tension in Newborn Infants.- Laboratory and Clinical Evaluation of a New Indwelling Oxygen Electrode for Continuous Monitoring of PaO2 in Neonates.- Continuous Intravascular PO2 Measurements with Catheter and Cannula Electrodes in Newborn Infants, Adults and Animals.- Routine Monitoring of the Arterial PO2 of Newborn Infants by Continuous Registration of Transcutaneous PO2 and Simultaneous Control of Relative Local Perfusion.- Clinical Experiences with Clamp Electrodes in Fetal Scalp for Simultaneous PO2 and ECG - Registration.- Discussion of Subsession: Oxygen Monitoring.- General Discussion of Session V.