With varying degrees of osteoporosis found in one of every four women older than 45 years of age and in nine out of ten women older than 75, as well as in men, osteoporosis is clearly a widespread disease with important health and economic impacts. It is also scientifically complex. In Osteoporosis: Pathophysiology and Clinical Management, leading clinicians and researchers join forces to illuminate in coupled chapters all the major scientific and clinical aspects of osteoporosis. By uniquely coupling basic and clinical chapters, the book illustrates the critical interdependence of investigators and practitioners. Traditional issues such as calcium supplementation and exercise are juxtaposed with state-of-the-art updates on molecular pharmacology and imaging. On the basic science side, topics range from the genetics of osteoporosis and bone turnover markers, to androgen action in bone, to the basic biology of estrogen and bone. On the clinical side the authors present the latest thinking about the use of bone densitometry in treatment, the use of vitamin D and its metabolites, and the clinical utilization of salmon calcitonin, as well as parathyroid and bisphosphonate therapies, SERMs, and other important treatments.
Unique in its integration of basic science and clinical practice, Osteoporosis: Pathophysiology and Clinical Management reveals the great progress that has occurred in the field, providing basic scientists with a clear view of the clinical state-of-the-art, and practicing physicians with a deeper understanding of the complex biology involved.

Klappentext

In Osteoporosis: Pathophysiology and Clinical Management, leading clinicians and researchers join forces to illuminate in coupled chapters all the major scientific and clinical aspects of osteoporosis. On the basic science side, topics range from the genetics of osteoporosis and bone turnover markers, to androgen action in bone, to the basic biology of estrogen and bone. On the clinical side the authors present the latest thinking about the use of bone densitometry in treatment, the use of vitamin D and its metabolites, and the clinical utilization of salmon calcitonin, as well as parathyroid and bisphosphonate therapies, SERMs, and other important treatments.

Inhalt

Human and Animal Studies of the Genetics of Osteoporosis Robert F. Klein and Tatiana Foroud The Genetics of Osteoporosis: Progress in Mice, not Man Ego Seeman Peak Bone Mass Acquisition Jean-Philippe Bonjour and René Rizzoli Peripheral Bone Mineral Assessment of the Axial Skeleton: Technical Aspects Thomas F. Lang and Jeffrey Duryea Use of Bone Densitometry in the Clinical Management of Osteoporosis John Shepherd, Chris Njeh, and Harry K. Genant Technical Aspects of Skeletal Assessment Using Quantitative Ultrasound Mary L. Bouxsein Clinical Aspects of Skeletal Assessment with Ultrasound Daniel T. Baran Molecular Markers of Bone Turnover: Basic and Analytical Aspects Berthold Fohr, Henning W. Woitge, and Markus J. Seibel Bone Turnover Markers: Their Place in the Investigation of Osteoporosis Richard Eastell and Penny R. Bainbridge Mechanical Influences on Bone Mass and Morphology: Investigating How Exercise May Regulate Adaptation in the Skeleton Stefan Judex and Clinton Rubin Exercise in the Prevention of Osteoporosis-Related Fractures Christine M. Snow and Belinda R. Beck The Physiology and Cell Biology of Calcium Transport in Relation to the Development of Osteoporosis Richard L. Prince and Paul Glendenning Calcium, Bone, and Life Robert P. Heaney Clinical Aspects of the Use of Vitamin D and Its Metabolites in Osteoporosis Ian R. Reid The Basic Biology of Estrogen and Bone Russell T. Turner, David Rickard, Thomas C. Spelsberg, and Jean D. Sibonga Clinical Trials of Estrogen and SERMs on Bone Markers, Bone Mineral Density, and Fractures Lorraine A. Fitzpatrick Androgen Action in Bone: Basic Cellular and Molecular Aspects Kristine M. Wiren Androgens and Skeletal Homeostasis: Potential ClinicalImplications of Animal Data Dirk Vanderschueren, Liesbeth Vandenput, Johannes V. Swinnen, Steven Boonen, and Roger Bouillon Gonadal Steroids and the Skeleton in Men: Clinical Aspects Benjamin Z. Leder and Joel S. Finkelstein Basic Aspects of Calcitonin in Skeletal Health Carlo Gennari Clinical Utilization of Salmon Calcitonin in the Treatment of Osteoporosis: Rationale, Supportive Data, and Considerations for the Future Charles H. Chesnut, III and Moïse Azria The Mechanism of Action of Nitrogen-Containing Bisphosphonates Alfred A. Reszka and Gideon A. Rodan Bisphosphonate Treatment of Osteoporosis Nelson B. Watts Basic Aspects of PTH in Skeletal Health Janet M. Hock Parathyroid Hormone as a Therapy for Osteoporosis Mishaela R. Rubin and John P. Bilezikian The Cellular and Molecular Aspects of Immunosuppressant Osteoporosis Mone Zaidi, Jameel Iqbal, Angela M. Inzerillo, Etsuko Abe, Li Sun, and Solomon Epstein Transplantation Osteoporosis Elizabeth Shane The Molecular Pharmacology of Osteoporosis Jameel Iqbal, Angela Inzerillo, Baljit S. Moonga, and Mone Zaidi Index