This book presents the proceedings of the IUTAM Symposium on Optimal Design and Control of Multibody Systems 2022, covering research papers in the realm of optimal structural and control design for both rigid and flexible multibody systems. It delves into the application of the adjoint approach, enabling the undertaking of extensive topology optimizations to unearth body designs that excel under time- and design-dependent loads. Encompassing presentations on (adjoint) sensitivity analysis, structural optimization, optimal control, robust optimization, artificial intelligence, machine learning, and computational methods and software development, the IUTAM Symposium 2022 showcased the latest breakthroughs and innovative methodologies. This book presents 14 meticulously peer-reviewed proceedings papers from the event, evenly split between the Optimal Design and Optimal Control panels.