Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years.
This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.

Inhalt

The Structure and Composition of the Yeast NPC.- The Vertebrate Nuclear Pore Complex: From Structure to Function.- How Ran Is Regulated.- Exportin-Mediated Nuclear Export of Proteins and Ribonucleoproteins.- Structures of Importins.- Nuclear Export of tRNA.- Nuclear Export of Messenger RNA.- Using Retroviruses to Study the Nuclear Export of mRNA.- Regulated Nuclear Transport.-