Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.

Inhalt

Epidemiology and Carcinogenesis.- Evidence from Animal Studies for the Carcinogenicity of Inhaled Diesel Exhaust.- Interpretation of Carcinogenicity and Effective Dose in Chronic Exposures of Rats to High Diesel Exhaust Concentrations.- Carcinogenicity of Dinitroarenes in Rat Lung.- In Vivo Metabolism and Genotoxic Effects of the Air Pollutant and Marker for Nitro-PAH's, 2-Nitrofluorene.- Chemistry, Detection, and Occurrence.- Nitroarenes: Their Detection, Mutagenicity and Occurrence in the Environment.- The Atmospheric Formation of Nitroarenes and Their Occurrence in Ambient Air.- Metabolism of 1-Nitropyrene Oxides and Effect of Nitrogen Dioxide on Arene Activation.- Molecular Mechanisms.- Mutagenic and Biochemical Consequences of the Reaction of Arylamines with DNA.- Mutagenesis Induced by a Single Acetylaminofluorene Adduct within the Narl Site is Position Dependent.- Unusual Hydrogen Bonding Patterns in 2-Aminofluorene (AF) and 2-Acetylaminofluorene (AAF) Modified DNA.- DNA Adduct Formation during Chronic Administration of an Aromatic Amine.- Aerial Oxidation of Acetylaminofluorene-Derived DNA Adducts.- Mutations and Homologous Recombination Induced by N-Substituted Aryl Compounds in Mammalian Cells.- Comparison of the Mutagenic Potency of DNA Adducts Formed by Reactive Derivatives of Aflatoxin, Benzidine and 1-Nitropyrene in a Plasmid System.- Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum.- DNA Adduct Formation by 1-Nitropyrene 4,5- and 9,10-Oxide.- Nitropolycyclic Aromatic Hydrocarbons and Diesel Exhaust: Potential Role of DNA Binding in Carcinogenicity.- Validation/Application of 32?-Postlabeling Analysis for the Detection of DNA Adducts Resulting from Complex Air Pollution Sources Containing PAHs and Nitrated PAHs.- Analysis of NO2-PAH DNA Adducts by Mass Spectrometry.- Metabolism.- Generation of Reactive Intermediates from 2-Nitrofluorene that Bind Covalently to DNA, RNA and Protein In Vitro and In Vivo in the Rat.- Activation of Carcinogenic N-Arylhydroxamic Acids by Peroxidase/H2O2/Halide Systems: Route to C-Nitroso Aromatics.- Biochemical Studies on the Putative Nitroso Metabolite of Chloramphenicol: A New Model for the Cause of Aplastic Anemia.- Mechanisms of FANFT/ANFT Induced Bladder Cancer.- Mutagenic Arylazides, Arylnitrenes, Arylnitrenium Ions.- Products Obtained by In Vitro Reaction of 4,5-Epoxy4,5-Dihydro-1-Nitropyrene with DNA.- Oxidative Metabolism of Nitrated Polycyclic Aromatic Hydrocarbons in Mammalian Cell Fractions.- Metabolic Activation of 6-Nitrochrysene and 6-Aminochrysene In Vitro and In Vivo.- Summary.- The Possible Role of Nitroarenes in Human Cancer.- Abstracts Presented at the Meeting.- Contributor Index.