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Nitric Oxide (NO) and Cancer

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Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representati... Weiterlesen
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Beschreibung

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.



Inhalt
PrefaceNitrous Oxide and CancerA role for eNOS in oncogenic Ras-driven cancerMultifaced Role of NItric Oxide in Cancer BiologyNitric oxide expression in cancerS-Nitrosylation: How Cancer Cells Say NO to Cell DeathCytotoxic and protective activity of nitric oxide cancersCytotoxic/protective activity of nitric oxide in cancerNitric oxide and life or death of human leukemia cellsInhibition of apoptosis by endogenous nitric oxide in chronic lymphomatic leukemiaNitric Oxide: a rate-limiting factor for metastases developmentNitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB-Snail-RKIP loopSensitizing effect of nitric oxide to cytotoxic stimuliNitric oxide is a promising enhancer for cancer therapyRole of Nitric Oxide for Modulation of Cancer Therapy ResistanceBreaking Resistance: Role of Nitric Oxide in the Sensitization of Cancer Cells to Chemo-ImmunotherapyPrognostic significance of iNOS and NO in human melanomaPrognostic significance of iNOS in heptatocellular carcinomaPrognostic significance pf iNOS in esophageal cancerPrognostic significance of nitrative DNA damage in infection and inflammatuion-related carcinogenesisNitric Oxide-releasing Melocules for Cancer Therapy and ChemopreventionNitric Oxide: monotherapy or sensitiser to conventional cancer treatmentsTherapeutic applications of nitric oxide for malignant tumor in animal models and human studiesS,R-3-Phenyl-4,5-dihydro-5-isoxazole Acetic Acide--Nitric Oxide GIT 27NO New Dress for Nitric Oxide MissionNitric Oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasisRole of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of HIF-1a: Potential role of Se-Methylselenocysteine (MSC),an antioxidant multi-targeted small molecule

Produktinformationen

Titel: Nitric Oxide (NO) and Cancer
Untertitel: Prognosis, Prevention, and Therapy
Editor:
EAN: 9781441914323
ISBN: 978-1-4419-1432-3
Digitaler Kopierschutz: Wasserzeichen
Format: E-Book (pdf)
Hersteller: Springer New York
Herausgeber: Humana Press
Genre: Medizin
Anzahl Seiten: 250
Veröffentlichung: 16.06.2010
Jahr: 2010
Dateigrösse: 8.3 MB