This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings. It includes lifestyle and supplement recommendations for beginning and maintaining autonomic nervous system and mitochondrial health and wellness. The book is organized around a six-pronged mind-body wellness program and contains a series of clinical applications and frequently asked questions. The physiologic need and clinical benefit and synergism of all six aspects working together are detailed, including the underlying biochemistry, with exhaustive references to statistically significant and clinically relevant studies. The book covers a range of clinical disorders, including anxiety, arrhythmia, atherosclerosis, bipolar disease, dementia, depression, fatigue, fibromyalgia, heart diseases, hypertension, mast cell disorder, migraine, and PTSD. Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, primary care, neurology, endocrinology, psychiatry, and integrative and functional medicine. It provides therapy options to the indications and diagnoses published in our book Clinical Autonomic Dysfunction (Springer, 2014).

Autorentext
Nicholas L. DePace, MD, FACCFranklin Cardiovascular AssociatesAutonomic Dysfunction and POTS CenterClinical Professor of MedicineHahnemann HospitalDrexel UniversityAttending Cardiologist Pennsylvania Hospital Penn MedicinePhiladelphia, PAUSA
Joseph Colombo, Ph.D.CTO & Senior Medical Director, TMCAMS, Inc.Parasympathetic & Sympathetic Nervous System ConsultantFranklin Cardiovascular AssociatesPhiladelphia, PAUSA

Inhalt
TABLE OF CONTENTSDISCLAIMER6FOREWORD7PREFACE8SUMMARY101.INTRODUCTION172.ABOUT THE PROGRAM18Energy Production21Back To The Program32The Importance of Antioxidants333.OMEGA-3 FATTY ACIDS (Prong-1)47Details of Oxidized LDL and Atherosclerosis Production51Fish Oil Omega-3s as an Anti-inflammatory54More Properties of Fish Oil66Summary of Cumulative Data704.NITRIC OXIDE (Prong-2)75The Universal Messenger77Detoxification and the Urea Cycle89Nitric Oxide Production92Beet Root Powder99L-Arginine100L-Citrulline105L-Carnitine109The Anti-Atherosclerotic Molecule110An Anti-Inflammatory Molecule113Erectile Dysfunction115An Antioxidant Molecule116Heart Failure117Nitric Oxide in the Nervous System124The Dark-Side of Nitric Oxide129Summary1335.OXIDATIVE STRESS REDUCTION (Prong-3)138Reduce Mitochondrial Dysfunction142Oxidative Stress150Markers of Oxidative Stress153Aldehydes: Oxidative stress and ROS production vs. Alpha-Lipoic Acid, as Modeled in Diabetes155Oxidative Stress in Cardiovascular Diseases159Oxidative Stress I: Biology and Cardiovascular Disease168Oxidative Stress II: Impact on the Heart and Vasculature170Oxidative Stress III: Cardiovascular Risk of Obesity, Diabetes, Smoking, and Pollution175Oxidative Stress and Aging176Homocysteine186Folic Acid (Vitamin B9)191Tryptophan192Oxidative Stress and Autonomic Neuropathy, Type II Diabetes as a Model196Application in Bipolar Disease221Application in Heart Failure223Application in Fatty Liver Disease226Application in Mast Cell Activation Syndrome and Food Allergies228Preventing the Dark-Side of Nitric Oxide2326.MEDITERRANEAN DIET (Prong-4)236Disease and the Mediterranean Diet239Endothelial Function and the Mediterranean Diet247Polyphenols and the Mediterranean Diet249The Mediterranean Diet: What To Expect250Health Benefits of Olive Oil253The Power of the Grape256The Incredible Whole Wheat Grain258Resveratrol262Antioxidant Effects263Mediterranean Diet Summary266Alcohol Consumption2737.EXERCISE (Prong-5)276Exercise and the Nervous System281Antioxidant Effects286Exercise and Endothelial Function288Exercise and Physical Activity2928.PSYCHOSOCIAL STRESS REDUCTION (PRONG-6)305Hypothalamus-Pituitary-Adrenal Axis Connects Brain and Body307The Nervous System's Brain-Body Connections314Modulation of Parasympathetic and Sympathetic Input to the Heart318Emotion and Sudden Arrhythmic Death322Emotions Modulate P&S Activity327Stress, Emotions, The Vagus Nerve, and Inflammation330Lateralization of Emotions and P&S Responses331The Brain-Heart Connection334Dentistry is Also Connected337The Vagus Nerve339The Brain-Gut Connection344Dynamic Parasympathetic Excess345Some Comments on Adrenal Fatigue349Reducing Stress is an Antioxidant3509.Mind-body wellness program benefits357Contra-Indications or Interactions357Alpha-Lipoic Acid Interactions357Coenzyme Q-10 Interactions358L-Arginine Interactions358L-Carnitine Interactions358L-Citrulline Interactions359<...