The writings of earliest civilizations reveal that diabetes mellitus has afflicted man for a very long time. Unfortunately, however, we are now experiencing a world-wide pandemic of the disease which has not been adequately addressed. Available evidence suggests that worldwide every 10 seconds one patient dies of diabetes and its severe complications. The outlook is even more bleak with the prediction of half of a billion diabetic patients by the year 2030. The cost-impact of the disease poses a major challenge for both developed and developing countries and their economies. Thus, it is high time to reconsider and revise the current strategies in diabetes care. Accordingly, a paradigm shift from reactive to perspective medicine has become a timely consideration. This shift is based on the concept of Predictive, Preventive and Personalized Medicine (PPPM). The rationale for PPPM relates to the recognition that prediction of persons at high risk for the disease (i.e., diabetes mellitus) should help devise strategies to prevent its target organ complications, and create effective treatments tailored to the individual patient, thereby reducing morbidity, and associated costs, and mortality.

The current book entitled "New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM" is intended to serve as a reference source for researchers and the healthcare industry with a special emphasis on health promotion in the general population and help design innovative strategies to prevent the onset of diabetes mellitus and its secondary complications.

Zusammenfassung
This book is intended to provide up-to-date and emerging information in the field of diabetes mellitus with a focus on preventive, predictive and personalized medicine.

Inhalt

Global Figures Argue in Favour of Preventive Measures and Personalised Treatment to Optimise Diabetes Care.- Three Levels of Prediction, Prevention & Individualised Treatment Algorithms to Advance Diabetes Care: Integrative Approach.- Diabetes mellitus: new challenges and innovative therapies.- Identification of Biomarkers for beta cell failure as detection tools for predictive screening in type 2 pre-Diabetes.- Endothelial dysfunction in diabetes: role of circulating biomarkers as potential diagnostic and prognostic tolls.- Endothelial progenitor dysfunction in the pathogenesis of diabetic retinopathy: treatment concept to correct diabetes-associated deficits.- Oxidative stress and apoptotic biomarkers in diabetic retinopathy.- Diabetic Retinopathy: the Need for Predictive, Preventive and Personalized Approach to Management.- The role of inflammatory cytokines in diabetic nephropathy: Potential use as predictive markers for early detection and progression.- Preventing hyperglycemia and tissue injury in diabetes: The dynamic role of 2,3 dioxygenase in diabetes and its complications.- An Integrative Approach to Chronic Wounds in Patients with Diabetes: PPPM in Action.- Understanding inflammation as the key to targeted preventive measures for diabetes in relation to periodontics.- Cancer predisposition in diabetics: risk assessment and targeted preventive measures.- Recognition of individual risks by analysis of subcellular imaging insights into chromium picolinate therapy in pre/diabetes care, search into its safety and opinion controversy.- Remote control in diabetes.- Drug delivery systems for predictive medicine: polymers as tools for advanced application.