A comprehensive survey of recent advances made in characterizing neurotransmitter transporters-including their imaging in the living brain-and in elucidating the processes underlying biological transport. The expert contributors present up-to-date findings on the molecular cloning of transporters and on neurotransmitter families both in plasma membranes and in storage vesicles. They also provide essential information on the structure-activity relationships for a multitude of recently synthesized dopamine uptake blockers, on transporter changes in the context of human drug abuse, and on the role of transporters in the action of uptake blockers in vivo. The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs of abuse, and neurotoxins.

Inhalt

The Structure and Function of Norepinephrine, Dopamine, and Serotonin Transporters, Sue L. Povlock and Susan G. Amara. Regulation of Antidepressant-Sensitive Serotonin Transporters, Randy D. Blakely, Sammanda Ramamoorthy, Yan Qian, Sally Schroeter, and Christopher C. Bradley. Mechanisms of Biogenic Amine Neurotransmitter Transporters, Gary Rudnick. Cloned Sodium- (and Chloride-) Dependent High-Affinity Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine, Joshua W. Miller, Daniel T. Kleven, Barbara A. Domin, and Robert T. Fremeau, Jr. Sodium-Coupled GABA and Glutamate Transporters: Structure and Function, Baruch I. Kanner. The High-Affinity Glutamate Transporter Family: Structure, Function, and Physiological Relevance, Yoshikatsu Kanai, Davide Trotti, Stephan Nussberger, and Matthias A. Hediger. Vesicular Neurotransmitter Transporters: Pharmacology, Biochemistry, and Molecular Analysis, Shimon Schuldiner. Neurotransmitter Transporter Proteins: Posttranslational Modifications, Amrat P. Patel. Dopamine Transporter Uptake Blockers: Structure-Activity Relationships, F. Ivy Carroll, Anita H. Lewin, and Michael J. Kuhar. Imaging Transporters for Dopamine and Other Neurotransmitters in Brain, Michael J. Kuhar, F. Ivy Carroll, Anita H. Lewin, John W. Boja, Ursula Scheffel, and Dean F. Wong. The Dopamine Transporter in Human Brain: Characterization and Effect of Cocaine Exposure, Deborah C. Mash and Julie K. Staley. Role of Axonal and Somatodendritic Monoamine Transporters in Action of Uptake Blockers, Nian-Hang Chen and Maarten E. A. Reith. Index.