Neurotransmitter changes taking place in the brain of patients with dementia disorders, mainly Alzheimer type dementia, are reported. Their role in the pathogenesis of Alzheimer's disease is discussed; and the neurochemical changes are considered as a base for formulating treatment strategies. By studying markers in the cerebrospinal fluid, diagnostic methods may be achieved that will aid in diagnosing subgroups of dememtia.

Inhalt

Some effects of CNS cholinergic neurons on memory.- Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization.- Changes of acetylcholine and choline concentrations in cerebrospinal fluids of normal subjects and patients with dementia of Alzheimer-type.- Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia.- CSF ?-endorphin, HVA and 5-HIAA of dementia of the Alzheimer type and Binswanger's disease in the elderly.- Neuropeptide levels in Alzheimer's disease and dementia with frontotemporal degeneration.- Changes in signal transduction in Alzheimer's disease.