A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Autorentext
Hiroshi Mitoma is Neurologist and Neurophysiologist , Professor and Chairman, Medical Education Promotion Center and Department Medical Education at Tokyo Medical University. Mario Manto is **Neurologist, Head of the Department of Neurology at the CHU-Charleroi, Professor of Neuroanatomy and Neurological Semiology at the University of Mons. He is also teaching Pathophysiology of the Nervous System. He is the Founding Editor of The Cerebellum, Cerebellum and Ataxias and has written or edited 10 books.

Inhalt

SECTION I. Fundamental pathogenic actions

1Overview of mechanisms underlying neuroimmune diseases

Korn T (Germany)

2 Roles of interleukines in neurological autoimmunity

Waisman A( Germany)

3 Roles of regulatory T cells in neurological autoimmunity

Hafler DA (USA)

4 Immune tolerance triggering neurological autoimmunity

Prabhaker BS (USA)

5 Disruption of blood-brain barrier and blood-nerve barrier: a key step in development of immune-mediated neurological diseases

Varatharaj A (UK)

6 Pathological mechanisms underlying production of autoantibodies

Zenker P (Australia)

7 Significance of autoantibodies: cause or result?

Dalmau J (USA), Lanchaster E (USA)

8 Multiple actions of microglia Kettenmann H (Germany)

9 Autoimmune astropathy

Bradl M (Australlia)

10 Genetic factors indicating susceptibility to neurological diseases

Baranzini SE (USA)

SECTION II. Clinical immunology: Pathogenesis, updated diagnostic criteria and novel therapeutic strategies

1 CNS neuroimmune diseases

11 General principles of immunotherapy

Vincent A (UK)

12 Multiple sclerosis

Brownlee WJ (UK)

13 Neuromyelitis optica: Diagnosis and therapies

Biousse V (USA)

14 Atypical inflammatory demyelinating syndrome

Hardy TA (Australia) 15 Central nervous system vasculitis

Benseler SM (Canada)

16 Neuro-Beçhet and Sjogren disease

Al-Araji A (UK)

17 Immune-mediated cortical encephalopathy (Limbic encephalitis)

Graus F (Spain)

18 Immune-mediated cerebellar ataxias

Hadjivassiliou M (UK)

19 Stiff-Person syndrome

Balint B (UK)

2 Peripheral neuroimmune diseases

20 Guillain-Barré syndrome

Goodfellow JA (UK) 21 Chronic inflammatory demyelinating polyneuropathy: Diagnosis and therapy

Said G (France)

22 Immune-mediated disorders of neuro-muscular junctions

Gilhus NE (Norway)

23 Myositis

Oldroyd A (UK)

3 Systemic neuroimmune diseases 24 Infection-related immune diseases

Hadjivassiliou M (UK)

25 Paraneoplastic neurological syndromes; Diagnosis and Therapies

Honnorat J (France)