The Immunology of Neurodegeneration: Linking Autoimmunity, Inflammation, and the Nervous System explores the fascinating and rapidly evolving interface between the immune system and the brain. Once thought to be an "immune-privileged" organ, the central nervous system (CNS) is now understood to be in constant dialogue with immune cells, cytokines, and antibodies. This book takes readers on a journey through the complex biology of neuroinflammation and its role in both health and disease.

Beginning with the fundamentals of immune homeostasis, tolerance, and repair, the early chapters lay the groundwork for understanding how self-reactivity can spiral into autoimmunity. The book then dives deep into the cellular and molecular players of neuroimmune cross-talk: B cells, unconventional T cells, microglia, astrocytes, and the chemokine networks that orchestrate CNS immunity.

Building on this foundation, disease-focused chapters examine how immune dysfunction contributes to multiple sclerosis, Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders such as ALS, Huntington's, and prion diseases. Each condition is explored through the lens of both classical pathology and cutting-edge immunology, offering readers a comprehensive view of how inflammation shapes neurodegeneration.

In addition to disease mechanisms, the book highlights the transformative role of emerging technologies?from single-cell sequencing to neuroimaging?in decoding the complex dynamics of neuroinflammation. The final chapters look forward, surveying the therapeutic landscape of vaccines, biologics, and immune modulators, while envisioning the promise of precision medicine at the brain?immune interface.

Written for researchers, clinicians, and students alike, this book bridges immunology and neuroscience to illuminate one of the most urgent frontiers in biomedical science. By linking autoimmunity, inflammation, and neurodegeneration, it provides not just a map of current knowledge but also a compass pointing toward future breakthroughs.