The past decade has witnessed significant progress in the diagnosis and treatment of nasopharyngeal cancer. Radiation therapy, used with curative intent, has undergone important technological advances, and combined chemotherapy and radiation has also become an established option. As a result, outcomes among patients with localized disease have improved markedly, with higher overall survival, better locoregional disease control, less treatment-induced toxicity, and better quality of life. However, most of the developments that have taken place are complex, and often not fully understood by physicians in general oncology practice without specialization in the treatment of head and neck cancer.

Against this background, Nasopharyngeal Cancer - Multidisciplinary Management aims to provide a comprehensive account of the current state of knowledge of nasopharyngeal cancer and its multidisciplinary management. The first ten chapters contain essential information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequent chapters examine in depth the various treatment options and explain combinations in a range of settings. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical options, follow-up, treatment of metastatic disease, treatment-related and complications and nasopharyngeal cancer in children. This is an important book that meets an urgent need and will prove essential reading for the oncology community worldwide.

Zusammenfassung

Nasopharyngeal Cancer - Multidisciplinary Management provides a comprehensive account of the current state of knowledge on nasopharyngeal cancer and its multidisciplinary management. The first ten chapters document contain essential background information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequently, the various treatment options and combinations in a range of settings are examined in depth. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical treatment, follow-up, treatment of metastatic disease, treatment-related complications, and nasopharyngeal cancer in children. This is an important book that will prove essential reading for the radiation oncology community worldwide and meet the need for substantial improvements in knowledge of modern techniques.

Inhalt
The Epidemiology of Nasopharyngeal Carcinoma.- Pathogenesis and Etiology of Nasopharyngeal Carcinoma.- Molecular Signaling Pathways in Nasopharyngeal Cancer.- Natural History, Presenting Symptoms, and Diagnosis of Nasopharyngeal Carcinoma.- Screening and Early Diagnosis of Nasopharyngeal Carcinoma.- Familial Nasopharyngeal Carcinoma.- Pathology of Nasopharyngeal Carcinoma.- Imaging in the Diagnosis and Staging of Carcinoma of Nasopharynx.- Prognostic Factors in Nasopharyngeal Cancer.- Early Stage Nasopharyngeal Cancer: A Highly Curative Disease with Radiation Therapy.- Drug Therapy for Nasopharyngeal Carcinoma: Cytotoxic and Targeted Therapy.- The Intergroup 0099 Trial for Nasopharyngeal Cancer: History, Perceptions, and Transitions.- Concurrent Chemotherapy-Enhanced Radiation: Trials and Conclusions.- Neoadjuvant Chemotherapy: Trials and Conclusions.- Adjuvant Chemotherapy for Nasopharyngeal Carcinoma.- Advances in the Technology of Radiation Therapy for Nasopharyngeal Carcinoma.- Selection and Delineation of Target Volumes in Intensity-Modulated Radiation Therapy for Nasopharyngeal Cancer.- Post-treatment Follow-Up of Patients with Nasopharyngeal Cancer.- Management of Patients with Failure Following Definitive Radiation Therapy: Reirradiation in Patients with Locally Recurrent Nasopharyngeal Carcinoma.- Surgery for Recurrent Nasopharyngeal Carcinoma.- Systemic Treatment for Incurable Recurrent and/or Metastatic Nasopharyngeal Carcinoma.- Long-Term Complications in the Treatment of Nasopharyngeal Carcinoma.- Nasopharyngeal Cancer in Pediatric and Adolescent Patients.- Staging of Nasopharyngeal Carcinoma.