The Third International Conference on Lymphatic Tissue and Germinal Centers in Immune Reactions was held at the University of Uppsala in Sweden, September 1-4, 1970. The conference is obliged to Professor K. E. Fichtelius for his initiative in establishing the meeting, as well as for the assistance of his staff at the Department of Histology in organizing the meetings. At the University of Uppsala inquiries into the lymphatic system go back to the 17th century and are marked by milestones, such as Olof Rudbeck's discovery of the thoracic duct in 1651 and August Hammar's fundamental work on the thymus in the beginning of this century. So one is justified to s~ that the conference gathered on historical ground. The organizing committee, naturally, hopes that the achievements presented at the conference will contribute to and provide significant advances in the history of lymphatic research. The material presented in this volume displ~s a great diversity of methods and the ingenuity of different investigators in their experimental designs. It is also apparent that contemporary research on lymphatic tissues or cells no longer recognizes the artificial borderline of morphologic ve~8U8 functional. It has become a multi­ disciplinary affair in which an increasing number of different specialists are working closely together. Apparently this is one reason why so many new and important discoveries have been made recently.

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September 1.- Session 1 Ontogeny and Phylogeny of Immune Response.- New Observations on lymph Gland (LMl) and Thymus Activity in Larval Bullfrogs, Rana Catesbeiana.- The Use of Surface Alloantigenic Markers to Study the Differentiation of Thymus-Derived Lymphocytes in Mice.- A New Theoretical Model of Plasma Cell Differentiation.- The Rabbit Appendix: A Central or Peripheral Lymphoid Organ?.- Immunoglobulin Gene Expression in Immunocyte Differentiation.- Chairman's introduction to discussion.- The Maturation of Lymphoid Tissue Structure and Function in Ontogeny.- Discussion.- Session 2 Origin and Interaction of Immunologically Active Cells.- Studies on the Transfer of Natural E. Coli Antibody Production in Rats.- Lymphoid Cells Reacting Against 'Self' and their Possible Role in Immune Responses.- In Vitro Interaction Between Bone Marrow-Derived and Thymus Cells.- Cell Interactions in the In Vitro Production of Antibodies to Chemically Defined Antigens.- Chairman's introduction to discussion.- Origin and Interaction of Immunologically Active Cells.- Discussion.- Invited Speaker of the Day:.- Interaction between T Cells and B Cells in Humoral Antibody Responses.- Session 3 Lymphoid Cell Migration.- Quantitative Studies of Thymocytokinetics.- Migration of Thymic Lymphocytes: Immunofluorescence and 3HTdR Labeling Studies.- Homing of Cells from the Bursa of Fabricius to Germinal Centers in the Chicken Spleen.- Immune Competence of Cells Derived from Hemopoietic Liver after Traffic to Thymus.- The Fate of Lymph-Borne Immunoblasts.- Massive Migration of Thymic Lymphocytes to Peyer's Patches in Neonatal Mice.- Chairman's introduction to discussion.- Lymphoid Cell Migration.- Discussion.- September 2.- Session 4 Lymphatic Tissue and Germinal Centers in Relation to Antibody Production.- Histological Changes of Lymphoid Tissues in Relation to the Ontogeny of the Immune Response in Germfree Piglets.- Sites of Specific Antibody Production after Injection of Human Serum Albumin (HSA) in Complete Freund-type Adjuvant in the Chicken.- Fate and Immunogenicity of Antigens Endocytosed by Macrophages.- Cellular and Immunological Events following Injection of Antigen into the Chicken Thymus.- Chairman's introduction to discussion.- Lymphatic Tissue and Germinal Centers in Relation to Antibody Production.- Discussion.- Session 5 Localization of Antigen and Immune Complexes in Lymphatic Tissue with Special Reference to Germinal Centers.- The Mechanism of Antigen Localization in Lymphoid Follicles and the Patterns of Localization of Tolerance-inducing Flagellar Proteins.- Accelerated and Enhanced Germinal Center Development in Regional Lymph Nodes of Mice Following Primary Stimulation with Antigen-Antibody Complexes as compared to Antigen Only.- Lymph Node Response to Antigen-Antibody Complexes and the Fate of Injected Primed Lymphocytes in a Tolerant Host.- Mechanism of Interaction between Immune Complexes and Receptors for Antibody on Macrophages.- Follicular Localization of Antigen: Possible Role of Lymphocytes Bearing a Receptor for Antigen-Antibody-Complement Complexes.- Chairman's introduction to discussion.- Localization of Antigen and Immune Complexes in Lymphatic Tissue, with Special Reference to Germinal Centers.- Discussion.- Invited Speaker of the Day:.- Role of Inductive Microenvironments on Hemopoietic (and Lymphoid?) Differentiation, and Role of Thymic Cells in the Eosinophilic Granulocyte Response to Antigen.- Session 6 Immunologically Active Cell Kinetics (Models).- An In Vitro Model System for the Study of the Induction of Cellular Immunity.- Primary Immune Reaction of Allogeneic Lymph Node Cells Against Tissue Antigens of Lethally Irradiated Hosts.- An Alternative Model of Antibody Forming Cell Differentiation.- A Quantitative Model for the Mechanism of Antibody Formation and Tolerance.- Chairman's introduction to discussion.- Modelling of the Immune Processes.- Discussion.- September 3.- Session 7 Regulation of Lymphatic Tissue Function.- Attempt to Separate Antibody-Forming Clones of Different Affinity for One Antigenic Determinant on a Macromolecule.- Cellular Immunity in Vitro; Specific Antigen Induces Sensitization and Activates a Nonspecific Cytolytic Effect.- Control of Lymphocyte Growth in Response to Phytohemagglutinin Stimulation.- Studies of the Mechanism of Prevention of Immunologic Deficiency in Suckling Dwarf Mice.- Chairman's introduction to discussion.- The Regulation of Antibody Formation.- Discussion.- Session 8 Modification of Immune Response by External Agents with Special Reference to Germinal Centers.- A Quantitative Assessment of Cellular Recovery in Lymphoid Tissue.- A Study of the Properties and Effects of Anti-Macrophage Sera.- Effect of L-Asparaginase on Thymus-Dependent Immune Reactivity.- The Ultrastructure of Antibody-Forming Spleen Cells in Immunologically Suppressed Leukemic Mice.- Effects of Antilymphocyte Serum on the Localization of 1251-Labeled Flagella, Colloidal Carbon, and Titanium Dioxide in Splenic Lymphoid Follicles.- Electron Microscopic Observations in Rat Lymph Nodes Following Injection of AMS and ATS.- Chairman's introduction to discussion.- Modification of the Immune Response by External Agents. An Introduction to the Discussion.- Discussion.- Invited Speaker of the Day:.- Surface Antigens of Immunocompetent Cells.- Session 9 Tolerance and Autosensitization.- The Side Effects of High Zone Tolerance.- The Mechanism of Breakdown of Immune Tolerance to Protein Antigen in Rabbits.- Presence of Antigen Binding Cells in Mice Tolerant to E. Coli Polysaccharide.- Cellular and Humoral Aspects of "High and Low Dose" Tolerance to Sheep Erythrocytes in Mice.- Comparative Studies of Antigen Injected into Adults and Neonatal Rabbits.- Chairman's introduction to discussion.- Induction and Termination of Immunological Unresponsiveness.- Discussion.- September 4.- Session 10 Neoplastic Disease and the Immune System.- Immunological Reactivity of Mice Injected with Leukemic Cells.- In Vitro Immunization for Immunotherapy.- Cellular Immunity, Its Serum Mediated Inhibition and Tumor-Distinctive Anergy to Tumors in Man.- Tumor Induction by Murine Leukemia/Sarcoma Viruses: Morphological and Immunological Studies.- Chairman's introduction to discussion.- Factors Contributing to the "Success" of Antigenic Tumours.- Discussion.- Session 11 Free Session.- Lymphofollicular Hyperplastic Responses in Ectopic Locations: Trachoma as a Paradigm.- The Bone Marrow Origin of Lymphoid Primary Follicle Small Lymph…