This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact withthe microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.

This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Autorentext
Prof. Dr. rer. nat. Steffen Backert
Chair of Microbiology
Friedrich Alexander University Erlangen/Nuremberg
Department of Biology
Division of Microbiology
Staudtstr. 5
D-91058 Erlangen
Germany
Tel. ++49 9131 8528081
Fax ++49 9131 8528082

Klappentext

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.

This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Inhalt

1. Nina Salama (Seattle, Washington, USA): Inflammation, immunity and vaccine development for the gastric pathogen Helicobacter pylori.-

2. Jay Solnick (Davis, California, USA): Impact of Helicobacter pylori virulence factors on the host immune system and development of gastric pathologies.-
3. Michael Naumann (Magdeburg, Germany): Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis.-
4. Emad El-Omar (Sydney, Australia): Genetic polymorphisms in inflammatory regulators control the prognosis of gastric cancer development.-
5. Richard Peek (Nashville, Tennessee, USA): Helicobacter pylori infection, inflammation and gastric carcinogenesis in animal models and gastroids.-
6. Georgina Hold (Sydney, Australia) or Martin Blaser (New York, USA): Impact of the gastrointestinal microbiome in health and disease: co-evolution with the host immune system.-
7. Yoshio Yamaoka (Oita, Japan): Importance of toll-like receptors in pro-inflammatory and anti-inflammatory responses by Helicobacter pylori.-
8. Richard Ferrero (Melbourne, Australia): Role of TIFA and Nod1 signaling in innate immunity against Helicobacter pylori infection.-
9. Sarah Linden (Gothenburg, Sweden): Carbohydrate-dependent and antimicrobial peptide defense mechanisms against Helicobacter pylori infection.-
10. Thomas Meyer (Berlin, Germany): Depletion of cholesterol by Helicobacter pylori prevents IFN signaling and escape of inflammatory responses.-
11. Anne Müller (Zürich, Switzerland): Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion and development of MALT lymphoma.-
12. Steffen Backert (Erlangen, Germany): Mechanisms of inflammasome signaling, micro RNA induction, cytokine dynamics and resolution of inflammation by Helicobacter pylori.-
13. Yongsheng Li (Chongqing , China): Resolution of cancer-promoting inflammation: a novel strategy for anti-cancer therapy.