Proceedings of the NATO Advanced Research Workshop on Molecular and Cellular Processes Underlying Desensitization and Adaptation to Signal Molecules held at Noordwijkerhout, The Netherlands, 29-31 May, 1986

Inhalt

Chemotaxis and Chemosensing.- Behavioral adaptation in prokaryotes.- Discussion.- Surface receptor mediated activation and adaptation of adenylate cyclase in Dictyostelium discoideum.- Discussion.- Adaptation of Dictyostelium discoideum cells to chemotactic signals.- Discussion.- Adaptation, periodic signalling, and receptor modification.- Discussion.- Adenylate Cyclase-Coupled Systems.- Glucagon desensitization of adenylate cyclase in hepatocytes: an action mediated by a distinct population of glucagon receptors coupled to stimulate inositol phospholipid metabolism.- Discussion.- Cellular adaptation to signal molecules: activation and interaction of different signal transduction systems.- Discussion.- Desensitization of the ?-adrenergic coupled adenylate cyclase. The ?-adrenergic receptor kinase phosphorylates agonist-occupied cyclase-coupled receptors.- Discussion.- Structural microheterogeneity of ß1-adrenoceptors in turkey erythrocytes and their functional consequences.- Discussion.- Adaptive response of beta-adrenergic sensitive adenylate cyclase system.- Discussion.- Hormone specific desensitization of Sertoli cell adenylate cyclase in a cell-free system.- Discussion.- Inositol Phospholipid-Coupled Systems.- Adaptations of receptor-dependent phosphatidylinositol 4,5-bisphosphate breakdown.- Discussion.- Cell responses to phosphoinositide-hydrolysing receptors: some potential sites of modulation.- Discussion.- The kinase C substrate protein B-50 and feedback control of synaptic signal transduction.- Discussion.- Retroinhibition of the calcium-phosphatidylinositol cascade by diacylglycerol in thyroid.- Discussion.- Visual Transduction.- Fast termination and adaptation processes in the cGMP cascade of visual transduction.- Discussion.- Phosphorylation of rhodopsin involved in terminating the visual response.- Discussion.- Ion Conductance.- Permeability control and desensitization by nicotinic acetylcholine receptors.- Discussion.- Cellular Systems.- Regulation of leukocyte responses to chemoattractants: role of receptors, guanine nucleotide regulatory (N) proteins and phospholipase C.- Modulation of macrophage oxygen metabolism. Evidence for desensitization and activation of the cell response to environmental stimuli.- Discussion.- Antibody induced down regulation of membrane receptors in human diseases.- Discussion.- Concluding Remarks.