Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin Structure and Actin-Binding Proteins) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data.
This book will appeal to research scientists seeking contemporary overviews of actin-myosin interaction and actin-based regulation. Contributors include senior scientists as well as the new breed of younger scientists.

Inhalt

An Overview of the Actomyosin Interactions.- Changes in Actin and Myosin Structural Dynamics Due to Their Weak and Strong Interactions.- Fluorescence Resonance Energy Transfer in Actomyosin Complexes.- Insights into Actomyosin Interactions from Actin Mutations.- Role of Charges in Actomyosin Interactions.- The Alanine-Scanning Mutagenesis of Dictyostelium Myosin II at the Ionic Interface with Actin.- Familial Hypertrophic Cardiomyopathic Myosin Mutations that Affect the Actin-Myosin Interaction.- Coupling Between Chemical and Mechanical Events and Conformation of Single Protein Molecules.- An Overview of Ca Regulation of Thin Filaments.- Cooperativity in the Ca2+ Regulation of Muscle Contraction.- Motility Assays of Calcium Regulation of Actin Filaments.- The Ultrastructural Basis of Actin Filament Regulation.- The Role of Troponin in the Ca2+ Regulation of Skeletal Muscle Contraction.- Structural Changes Between Regulatory Proteins and Actin: A Regulation Model by Tropomyosin-Troponin Based on FRET Measurements.