The development of a proper theoretical description of the living world today poses one of the most significant challenges to science. In this interdisciplinary work, leading scientists in biology, physics, computer science and mathematics have joinded forces to present and tackle some of the open problems. They demonstrate that the concepts and methods of the newly developed fields of nonlinear dynamics and complex systems theory, combined with irreversible thermodynamics and far-from-equilibrium statistical mechanics, enable us to make progress with many of these problems. The book will interest all researchers and students involved in seeking an integrative approach to the frontiers of biological science.

Klappentext

The development of a proper description of the living world today stands as one of the most significant challenges to physics. A variety of new experimental techniques in molecular biology, microbiol­ ogy, physiology and other fields of biological research constantly expand our knowledge and enable us to make increasingly more detailed functional and structural descriptions. Over the past decades, the amount and complexity of available information have multiplied dramatically, while at the same time our basic understanding of the nature of regulation, behavior, morphogenesis and evolution in the living world has made only modest progress. A key obstacle is clearly the proper handling of the available data. This requires a stronger emphasis on mathematical modeling through which the consistency of the adopted explanations can be checked, and general princi­ ples may be extracted. As an even more serious problem, however, it appears that the proper physical concepts for the development of a theoretically oriented biology have not hitherto been available. Classical mechanics and equilibrium thermody­ namics, for instance, are inappropriate and useless in some of the most essen­ tial biological contexts. Fortunately, there is now convincing evidence that the concepts and methods of the newly developed fields of nonlinear dynam­ ics and complex systems theory, combined with irreversible thermodynamics and far-from-equilibrium statistical mechanics will enable us to move ahead with many of these problems.

Inhalt

I Pattern Formation in Chemical Systems.- Spiral Waves in Bounded Excitable Media.- Dynamics of Oscillatory Chemical Systems.- Localized Turing and Turing-Hopf Patterns.- II Biological Patterns.- Domains and Patterns in Biological Membranes.- Modelling Pattern Formation on Primate Visual Cortex.- III Dynamics of Biological Macromolecules.- Channel Function and Channel-Lipid Bilayer Interactions.- Dynamics of Nucleic Acids and Nucleic Acid:Protein Complexes.- IV Physiological Control Systems.- Models of Renal Blood Flow Autoregulation.- Dynamics of Bone Remodelling.- Modelling Heart Rate Variability Due to Respiration and Baroreflex.- A Dynamical Approach to Normal and Parkinsonian Tremor.- V Complex Ecologies and Evolution.- Dynamics of Complex Ecologies.- A Self-Organized Critical Model for Evolution.