This book constitutes the refereed post-conference proceedings of the 19th International Conference on Mobile and Ubiquitous Systems: Computing, Networking and Services, MobiQuitous 2022, which was held in Pittsburgh, November 14-17, 2022. The conference was held virtually due to the COVID-19 pandemic. The 26 full and 2 short papers were carefully reviewed and selected from 95 submissions and present discussions, They were organized in topical sections as follows: Internet of Things (IoT), Security and Privacy, Human-centric sensing, Drone applications and edge computing, Wireless networks, Mobile and human computer interactions, Poster and demo sessions, Technology for health