This new volume introduces the applications of microfluidic systems to facilitate biotechnological and biomedical processes. It provides an overview on cutting-edge technologies, summarizes traditional and modern fabrication methods and highlights recent advances regarding the application of lab-on-a-chip (LoC) systems for bioanalytical purposes. This book is ideal for research scientists and students interested at the cross-section between biotechnology, chemistry and chemical engineering.

Autorentext

Janina Bahnemann (born 1985) is Professor of Life Sciences at the Institute of Physics at the University of Augsburg, Germany, since 2022. She studied Life Science (Bachelor and Master studies) at the Leibniz University Hannover from 2004 to 2009. In 2014, she completed her PhD studies at the Hamburg University of Technology in the Institute of Bioprocess and Biosystems Technology. In 2015, Janina Bahnemann joined the California Institute of Technology (Caltech, USA) as a postdoctoral fellow, where she worked at the Institute for Environmental and Applied Sciences in the group of Prof. Michael Hoffmann. In 2017, she was awarded the competitive Emmy Noether fellowship of the German Research Foundation (DFG). From 2017 to 2022, she headed her independent Emmy Noether junior research group at the Institute of Technical Chemistry, Leibniz University Hannover, and held a substitute professorship at the Faculty of Technology at Bielefeld University from 2021 to 2022. Her research focuses on biotechnology, cell culture and microsystems technology as well as the development of lab-on-a-chip systems and biosensors for biotechnological and medical applications. Alexander Grünberger (born 1985) is Junior professor for Multiscale Bioengineering at the University of Bielefeld. He studied Bioengineering at the Karlsruhe Institute of Technology (KIT), the University of Queensland (Australia) and the University of Delaware (USA) from 2004 to 2010. In 2014, he completed his PhD at the RWTH Aachen University under the supervision of Prof. Wolfgang Wiechert in the field of microfluidic single cell analysis. In 2014 he was awarded both the Bioeconomy PhD Award of the Bioeconomy Science Center of NRW and the Klaus-Goerttler Promotions Award of the German Society for Flow Cytometry. In 2015, he received the VAAM PhD Award of the Association for General and Applied Microbiology followed by a "Helmholtz Postdoctoral Fellowship" in 2016. In 2017 he was appointed to the newly established Chair of Multiscale Bioengineering at the University of Bielefeld. His research focus is the development and application of novel microfluidic single-cell cultivation systems for application in biotechnology and bioprocess engineering.

Inhalt

Microfluidics in Biotechnology: Overview and Status Quo.- A Primer on Microfluidics: From Basic Principles to Microfabrication.- Emerging technologies and materials for high-resolution 3D printing of microfluidic chips.- Microbioreactors for process development and cell-based screening studies.- Microfluidic Devices as Process Development Tools for Cellular Therapy Manufacturing.- Droplet Microfluidics for Microbial Biotechnology.- Microfluidic Single-Cell Analytics.- Analytics in microfluidic systems.- Biocatalysis in Continuous-Flow Microfluidic Reactors.- Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics.- Microfluidics for Environmental Applications.- Microfluidic Systems for Antimicrobial Susceptibility Testing.- Organ-on-a-Chip.- Emerging Biosensor Trends in Organ-on-a-Chip.- Microfluidics in Biotechnology: Quo vadis.