Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.

Inhalt
The Obesity Epidemic: A Global Perspective.- Global Dynamics in Childhood Obesity: Reflections on a Life of Work in the Field.- The Neuroendocrine Perspective: The Control of Appetite and Energy Expenditure.- The Neuroendocrine Control of Energy Balance.- The Genetics of Childhood Obesity.- Monogenic Obesity.- Syndromic Obesity.- Polygenic Obesity.- Racial Differences in Childhood Obesity: Pathogenesis and Complications.- Pre- and Perinatal Determinants of Childhood Obesity.- Maternal Determinants of Childhood Obesity: Weight Gain, Smoking, and Breastfeeding.- Intrauterine Growth Retardation.- Gestational Diabetes.- The Roles of Diet and Energy Expenditure in Obesity Pathogenesis.- The Role of Diet.- Energy Expenditure in Children: The Role of NEAT.- Metabolic Complications of Childhood Obesity.- Childhood Obesity and the Regulation of Growth, Thyroid Function, Sexual Development, and Calcium Homeostasis.- Pathogenesis of Insulin Resistance and Glucose Intolerance in Childhood Obesity.- Pathogenesis and Management of Dyslipidemia in Obese Children.- Fatty Liver Disease.- Pathogenesis of Hypertension and Renal Disease in Obesity.- Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity.- The Long-Term Metabolic Complications of Childhood Obesity.- Childhood Obesity, Atherogenesis, and Adult Cardiovascular Disease.- Treatment of Childhood Obesity: Lifestyle Intervention.- Family-Based Behavioral Interventions.- Exercise and Childhood Obesity.- School- and Community-Based Interventions.- Management of Obesity with Complications: Pharmacotherapy and Bariatric Surgery.- Pharmacotherapy of Childhood Obesity and Pre-diabetes.- Pathogenesis and Management of Adiposity and Insulin Resistance in PCOS: Prevention and Treatment of the Metabolic Disease Components.- Obesity and Metabolic Dysfunction in the Child with a Major Behavioral Disorder: Atypical Antipsychotics.- Hypothalamic Obesity.- Bariatric Surgery in Adolescents.- Challenges to Long-Term Success.- Neuroendocrine and Metabolic Adaptations in the Central Nervous System That Facilitate Weight Regain.- The Socio-cultural Context for Obesity Prevention and Treatment in Children and Adolescents: Influences of Ethnicity and Gender.- The Future of Childhood Obesity in the Global Marketplace.- The Marketing and Distribution of Fast Food.- Local and National Policy-Based Interventions: To Improve Children's Nutrition.