Introduction to Meta-Analysis

A clear and thorough introduction to meta-analysis, the process of synthesizing data from a series of separate studies

The first edition of this text was widely acclaimed for the clarity of the presentation, and quickly established itself as the definitive text in this field. The fully updated second edition includes new and expanded content on avoiding common mistakes in meta-analysis, understanding heterogeneity in effects, publication bias, and more. Several brand-new chapters provide a systematic "how to" approach to performing and reporting a meta-analysis from start to finish.

Written by four of the world's foremost authorities on all aspects of meta-analysis, the new edition:

• Outlines the role of meta-analysis in the research process

• Shows how to compute effects sizes and treatment effects

• Explains the fixed-effect and random-effects models for synthesizing data

• Demonstrates how to assess and interpret variation in effect size across studies

• Explains how to avoid common mistakes in meta-analysis

• Discusses controversies in meta-analysis

• Includes access to a companion website containing videos, spreadsheets, data files, free software for prediction intervals, and step-by-step instructions for performing analyses using Comprehensive Meta-Analysis (CMA)

Download videos, class materials, and worked examples at www.Introduction-to-Meta-Analysis.com

"This book offers the reader a unified framework for thinking about meta-analysis, and then discusses all elements of the analysis within that framework. The authors address a series of common mistakes and explain how to avoid them. As the editor-in-chief of the American Psychologist and former editor of Psychological Bulletin, I can say without hesitation that the quality of manuscript submissions reporting meta-analyses would be vastly better if researchers read this book."
--Harris Cooper, Hugo L. Blomquist Distinguished Professor Emeritus of Psychology and Neuroscience, Editor-in-chief of the American Psychologist, former editor of Psychological Bulletin

"A superb combination of lucid prose and informative graphics, the authors provide a refreshing departure from cookbook approaches with their clear explanations of the what and why of meta-analysis. The book is ideal as a course textbook or for self-study. My students raved about the clarity of the explanations and examples."
--David Rindskopf, Distinguished Professor of Educational Psychology, City University of New York, Graduate School and University Center, & Editor of the Journal of Educational and Behavioral Statistics

"The approach taken by Introduction to Meta-analysis is intended to be primarily conceptual, and it is amazingly successful at achieving that goal. The reader can comfortably skip the formulas and still understand their application and underlying motivation. For the more statistically sophisticated reader, the relevant formulas and worked examples provide a superb practical guide to performing a meta-analysis. The book provides an eclectic mix of examples from education, social science, biomedical studies, and even ecology. For anyone considering leading a course in meta-analysis, or pursuing self-directed study, Introduction to Meta-analysis would be a clear first choice."
--Jesse A. Berlin, ScD

Autorentext

Michael Borenstein is the Director of Biostat, a leading developer of statistical software. He is the primary developer of Comprehensive Meta-Analysis (CMA), the world's most widely used program for meta-analysis. He is the recipient of numerous grants from the NIH to develop methods, software, and educational materials for meta-analysis. He has lectured widely on meta-analysis, including at the NIH, CDC, and FDA.

Larry V. Hedges is Board of Trustees Professor of Statistics and Education and Social Policy, Professor of Psychology, Professor of Medical Social Sciences, and IPR Fellow, Northwestern University, USA. He is a national leader in the fields of educational statistics and evaluation and is an elected member of many leading associations.

Julian P.T. Higgins is Professor of Evidence Synthesis at the University of Bristol, UK, and a National Institute for Health Research (NIHR) Senior Investigator. He has had numerous core roles in the Cochrane Collaboration, including editing its methodological Handbook since 2003. His many contributions to meta-analysis include the foundation of network meta-analysis, methods for describing and explaining heterogeneity and a general framework for individual participant data meta-analysis. He is a Highly Cited Researcher with over a quarter of a million citations to his work and has been a recipient of the Ingram Olkin Award for distinguished lifetime achievement in research synthesis methodology.

Hannah R. Rothstein is Professor of Management at Baruch College and the Graduate Center of the City University of New York. She is a Fellow of the American Psychological Association and a past President of the Society for Research Synthesis Methodology. She is former Editor-in-Chief of Research Synthesis Methods and serves on the editorial boards of Psychological Bulletin, Psychological Methods, and Organizational Research Methods. Professor Rothstein is a co-developer of the Comprehensive Meta-Analysis software and has published numerous systematic reviews and meta-analyses.

Klappentext

This book provides a clear and thorough introduction to meta-analysis, the process of synthesizing data from a series of separate studies. The first edition of this text was widely acclaimed for the clarity of the presentation, and quickly established itself as the definitive text in this field. The fully updated second edition includes new and expanded content on avoiding common mistakes in meta-analysis, understanding heterogeneity in effects, publication bias, and more. Several brand-new chapters provide a systematic "how to" approach to performing and reporting a meta-analysis from start to finish.

Written by four of the world's foremost authorities on all aspects of meta-analysis, the new edition:

• Outlines the role of meta-analysis in the research process
• Shows how to compute effects sizes and treatment effects
• Explains the fixed-effect and random-effects models for synthesizing data
• Demonstrates how to assess and interpret variation in effect size across studies
• Explains how to avoid common mistakes in meta-analysis
• Discusses controversies in meta-analysis
• Includes access to a companion website containing videos, spreadsheets, data files, free software for prediction intervals, and step-by-step instructions for performing analyses using Comprehensive Meta-Analysis (CMA)¯(TM)

Download videos, class materials, and worked examples at www.Introduction-to-Meta-Analysis.com

Inhalt

List of Tables xv

List of Figures xix

Acknowledgements xxv

Preface xxvii

Preface to the Second Edition xxxv

Website xxxvii

Part 1: Introduction

1 How a Meta-Analysis Works 3

Introduction 3

Individual studies 3

The summary effect 5

Heterogeneity of effect sizes 6

Summary points 7

2 Why Perform a Meta-Analysis 9

Introduction 9

The streptokinase meta-analysis 10

Statistical significance 11

Clinical importance of the effect 11

Consistency of effects 12

Summary points 13

Part 2: Effect Size and Precision

3 Overview 17

Treatment effects and effect sizes 17

Parameters and estimates 18

Outline of effect size computations 19

4 Effect Sizes Based On Means 21

Introduction 21

Raw (unstandardized) mean difference D 21

Standardized mean difference, d and g 25

Response ratios 30

Summary points 31

5 Effect Sizes Based On Binary Data (2 × 2 Tables) 33

Introduction 33

Risk ratio 33

Odds ratio 35

Risk difference 37

…