This is the first book that discusses subjects of diagnosis, therapy, therapy assessment, and prognosis of breast cancer in one single volume. Cancer killed 6.7 million people around the world in 2002 and this figure is expected to rise to 10.1 million in 2020. Approximately, 189,510 new cases of breast cancer were reported in 2007 in the United States, and 40,910 died in the same year. Focusing on Breast Carcinoma, this first volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis brings together 56 leading scientists from around the world to deliver a comprehensive treatise on all aspects of breast cancer, including diagnosis, treatments and prognosis. Scientists and clinicians have contributed state of the art chapters on their respective areas of expertise providing the reader a whole field view of breast cancer management. This fully illustrated volume: Presents a constructive evaluation of commonly used methods for elucidating primary and secondary cancer initiation, progression, relapse, and metastasis. Highlights methods of breast cancer diagnosis and treatment assessment including various imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging, immunohistochemistry and histochemistry. Discusses detailed therapeutic protocols, including both their benefits and side-effects. Discusses examples of breast cancer treatments includingchemotherapy, radiation, chemoradiation, surgery, hormonal - and immunotherapy Details the molecular processes that lead to the development and proliferation of cancer cells Includes recent major advances in cancer diagnosis and therapy assessment Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editinga must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

Zusammenfassung
The enormity of the global healthcare costs vical. One-fifth of all cancers worldwide as a result of cancer infliction cannot be are caused by a chronic infection, for overemphasized. There are more than 100 example, human papilloma virus (HPV) types of cancers; any part of the body can causes cervical cancer and hepatitis B be affected. More than 11 million people virus (HBV) causes liver cancer. Tobacco are diagnosed with cancer every year, and use is the most common preventable cause it is estimated that there will be 16 mil- of cancer in the world. Approximately, lion new cases per year by the year 2020. 168,000 cancer deaths are expected to be In 2005, 7. 6 million people died of can- caused by tobacco use. Approximately, cer, that is, 13% of the 58 million deaths 40% of cancer could be prevented, mainly worldwide. It is estimated that 9 million by not using tobacco, having a healthy people will die from cancer worldwide in diet, being physically active, preventing 2015 and 11. 4 million will die in 2030. infections that may cause cancer, reduc- More than 70% of all cancer deaths occur ing exposure to sunlight, and avoidance of in low and middle income countries. excessive alcohol consumption and stress Five major cancer causing overall mor- (anger). A third of cancers could be cured talities per year worldwide are (WHO): if detected early and treated adequately. It is well established that scientific 1. Lung: 1.

Inhalt
Breast Cancer: An Introduction.- Breast Cancer: Computer-Aided Detection.- Sebaceous Carcinoma of the Breast: Clinicopathologic Features.- Breast Cancer: Detection by In-Vivo Imaging of Angiogenesis.- Breast and Prostate Biopsies: Use of Optimized High-Throughput MicroRNA Expression for Diagnosis (Methodology).- Familial Breast Cancer: Detection of Prevalent High-Risk Epithelial Lesions.- Differentiation Between Benign and Malignant Papillary Lesions of Breast: Excisional Biopsy or Stereotactic Vacuum-Assisted Biopsy (Methodology).- Multicentric Breast Cancer: Sentinel Node Biopsy as a Diagnostic Tool.- Breast Cancer Recurrence: Role of Serum Tumor Markers CEA and CA 15-3.- Breast Cancer Patients Before, During or After Treatment: Circulating Tumor Cells in Peripheral Blood Detected by Multigene Real-Time Reverse Transcriptase-Polymerase Chain Reaction.- Breast Cancer Patients: Diagnostic Epigenetic Markers in Blood.- Breast Cancer Patients: Detection of Circulating Cancer Cell-Related mRNA Markers with Membrane Array Method.- Prediction of Metastasis and Recurrence of Breast Carcinoma: Detection of Survivin-Expressing Circulating Cancer Cells.- Node-Negative Breast Cancer: Predictive and Prognostic Value of Peripheral Blood Cytokeratin-19 mRNA-Positive Cells.- Breast and Colon Carcinomas: Detection with Plasma CRIPTO-1.- Breast Cancer Risk in Women with Abnormal Cytology in Nipple Aspirate Fluid.- Tissue Microarrays: Construction and Utilization for Biomarker Studies.- Systematic Validation of Breast Cancer Biomarkers Using Tissue Microarrays: From Construction to Image Analysis.- Phyllodes Tumors of the Breast: The Role of Immunohistochemistry in Diagnosis.- Phyllodes Tumor of the Breast: Prognostic Assessment Using Immunohistochemistry.- Metaplastic Breast Carcinoma:Detection Using Histology and Immunohistochemistry.- Invasive Breast Cancer: Overexpression of HER-2 Determined by Immunohistochemistry and Multiplex Ligation-Dependent Probe Amplification.- Operable Breast Cancer: Neoadjuvant Treatment (Methodology).- Chemotherapy for Breast Cancer.- Locally Advanced Breast Cancer: Role of Chemotherapy in Improving Prognosis.- Relevance of Dose-Intensity for Adjuvant Treatment of Breast Cancer.- Advanced Breast Cancer: Treatment with Docetaxel/Epirubicin.- Systemic Therapy for Breast Cancer: Using Toxicity Data to Inform Decisions.- Chemotherapy for Metastatic Breast Cancer Patients Who Received Adjuvant Anthracyclines (An Overview).- Estrogen Receptor-Negative and HER-2/neu-Positive Locally Advanced Breast Carcinoma: Therapy with Paclitaxel and Granulocyte-Colony Stimulating Factor.- Breast Cancer: Side Effects of Tamoxifen and Anastrozole.- Breast Cancer: Expression of HER-2 and Epidermal Growth Factor Receptor as Clinical Markers for Response to Targeted Therapy.- Young Breast Cancer Patients Undergoing Breast-Conserving Therapy: Role of BRCA1 and BRCA2.- Radiation Therapy for Older Women with Early Breast Cancer.- Acute Side Effects of Radiotherapy in Breast Cancer Patients: Role of DNA-Repair and Cell Cycle Control Genes.- 18F-Fluorodeoxyglucose/Positron Emission Tomography in Primary Breast Cancer: Factors Responsible for False-Negative Results.- Sentinel Lymph Node Surgery During Prophylactic Mastectomy (Methodology).- Breast Conservation Surgery: Methods.- Lymph Node-Negative Breast Carcinoma: Assessment of HER-2/neu Gene Status as Prognostic Value.- Multifocal or Multicentric Breast Cancer: Understanding Its Impact on Management and Treatment Outcomes.- Are Breast Cancer Survivors at Risk for Developing Other Cancers?.- Distant Metastasis in Elderly Patients with Breast Cancer: Prognosis with Nodal Status.- Concomitant Use of Tamoxifen with Radiotherapy Enhances Subcutaneous Breast Fibrosis in Hypersensitive Patients.- Malignant Phyllodes Tumor of the Breast: Is Adjuvant Radiotherapy Necessary?.- Locally Advanced Breast Cancer: Multidrug Resistance.- Breast Cancer: Diagnosis of Recurrence Using 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography.- Role of Sentinel Lymph Node Biopsy in Ductal Carcinoma In Situ: Diagnosis and Methodology.- Breast Conservation Treatment of Early Stage Breast Carcinoma: Risk of Cardiac Mortality.