The use of porphyrins for localization and photodynamic therapy of neoplastic disease has been the topic of several international symposia, reviews and books during the preceeding five years. The literature on this topic has continued to grow, as have numbers of presentations at national and international meetings relating to photobiology, chemistry, and lasers. In this volume, it is the intention of the editor to provide both information on current research projects, and detailed methodology used in such investigations. A bibliography on the subjects of porphyrin localization and therapy is included. The manuscripts contained in this volume are based on reports given at a Porphyrin Photosensitization Workshop which was held in Philadel­ phia, July 6-7, 1984. This Workshop was supported by NIH grant CA 36746, together with funds from the Fogarty International Center. Authors were requested to update their contributions to provide a summary of progress to mid 1985. Manuscripts containing material not presented in Philadelphia are also included, notably a series of articles describ­ ing current clinical and pre-clinical results from China. Since the Philadelphia Workshop, a meeting was held in Alghero, Sardinia (May, 1985), and additional conferences are now being planned; this attests to the continued interest in photodynamic therapy involving porphyrin photo­ sensitization.

Inhalt

Hematoporphyrin Photodynamic Therapy for Transitional Cell Carcinoma of the Bladder - An Update.- Photodynamic Therapy in the Management of Cancer: An Analysis of 114 Cases.- Preliminary Results of Hematoporphyrin Derivative-Laser Treatment for 13 Cases of Early Esophageal Carcinoma.- Optimalization of the Depth of Selective Response of Neoplastic Tissue..- Dosimetry Methods in Photoradiation Therapy.- Fluorescence Diagnosis of Cancer.- Studies of HPD and Radiolabelled HPD in Vivo and in Vitro.- Photodynamic Effects and Hyperthermia in Vitro.- Preliminary Studies with Implanted Polyvinyl Alcohol Sponges as a Model for Studying the Role of Neointerstitial and Neovascular Compartments of Tumors in the Localization, Retention and Photodynamic Effects of Photosensitizers.- Quantitative Studies of Tetraphenylporphinesulfonate and Hematoporphyrin Derivative Distribution in Animal Tumor Systems.- Correlation of Tumor Blood Flow to Tumor Regression After Hematoporphyrin Derivative (HPD) Photodynamic Therapy to Transplantable Bladder Tumors.- The Biological Effects of Photodynamic Therapy on Normal Skin in Mice-I. A Light Microscopic Study.- The Biological Effects of Photodynamic Therapy on Normal Skin in Mice-II. An Electron Microscopic Study.- Studies on Hematoporphyrin Photosensitized Effects on Human Cancer Cells in Vitro: Tem and Sem Observations.- Photodynamic Effect of Hematoporphyrin on Human Cancer Cells and Normal Diploid Fibroblasts in Vitro.- Phototoxic Effects of Hematoporphyrin Derivative and Its Chromatographic Fractions on Hormone-Producing Malignant Trophoblast Cells in Vitro.- Examination of Potentilly Lethal Damage in Cells Treated with Hematoporphyrin Derivative and Red Light.- Porphyrin Photosensitization of Bacteria.- Photosensitization of Mitochondrial Adenosine-Triphosphate and Adenylate Kinase by Hematoporphyrin Derivative in Vivo.- Porphyrin-Membrane Interactions: Structural, Kinetic and Thermodynamic Aspects Studied Using Fluorescence Techniques.- Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I.- Binding of Porphyrins to Serum Proteins.- Separation of Different Fractions of Hematoporphyrin Derivative by a Two-Phase Extraction System.- Chemical, Biologic and Biophysical Studies on 'Hematoporphyrin Derivative'.- Some Preparations and Properties of Porphyrins.- The Structure of Protoporphyrin and of the Aggregate Fraction of Haematoporphyrin Derivative in Solution.- Chemical Manipulation of the Vinyl Groups in Protoporphyrin-IX..- Aggregation Effects on the Photophysical Properties of Porphyrins in Relation to Mechanisms Involved in Photodynamic Therapy.- Studies on the Solvophobic Nature of Porphyrin Self Aggregation Vs. The Lipophilic Nature of Porphyrin-Membrane Binding.- Photodynamic Therapy.