Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, this book is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Lucia Banci is a bioinorganic chemist and a structural biologist who is studying, among various topics, metal transport and metal homeostasis processes. She is aiming towards a cellular perspective in the spirit of mechanistic systems biology, with the goal of describing functional processes with atomic resolution in a cellular context.

Klappentext

Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, this book is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Lucia Banci is a bioinorganic chemist and a structural biologist who is studying, among various topics, metal transport and metal homeostasis processes. She is aiming towards a cellular perspective in the spirit of mechanistic systems biology, with the goal of describing functional processes with atomic resolution in a cellular context.

Zusammenfassung
Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Inhalt

1. Metallomics: Some Definitions and General Comments by Lucia Banci and Ivano Bertini

2. Technologies for Detecting Metals in Single Cells by James E. Penner-Hahn

3. Sodium/Potassium Homeostasis in the Cell by Michael V. Clausen and Hanne Poulsen

4. Cellular Magnesium Homeostasis in Mammalian Cells by Andrea M. P. Romani

5. Intracellular Calcium Homeostasis and Signaling by Marisa Brini, Tito Cali, Denis Ottolini, and Ernesto Carafoli

6. Manganese Homeostasis and Transport by Jerome Roth, Silvia Ponzoni, and Michael Aschner

7. Control of Iron Metabolism in Bacteria by Ian Norton, Arvindkumar S. Salunkhe, Helen Goodluck, Wafaa S. M. Aly, Hanna Mourad-Agha, Pierre Cornelis, and Simon Andrews

8. The Iron Metallome in Eukaryotic Organisms by Adrienne C. Dlouhy and Caryn E. Outten

9. Heme Uptake and Metabolism in Bacteria by David R. Benson and Mario Rivera

10. Cobalt and Corrinoid Transport and Biochemistry by Valentin Cracan and Ruma Banerjee 11. Nickel Metallomics: General Themes Guiding Nickel Homeostasis by Andrew M. Sydor and Deborah B. Zamble 12. The Copper Metallome in Prokaryotic Cells by Christopher Rensing and Sylvia Franke McDevitt

13. The Copper Metallome in Eukaryotic Cells by Katherine E. Vest, Hayaa F. Hashemi, and Paul A. Cobine

14. Zinc and the Zinc Proteome by Wolfgang Maret

15. Metabolism of Molybdenum by Ralf R. Mendel

16. Comparative Genomics Analysis of the Metallomes by Vadim N. Gladyshev and Yan Zhang