The three-volume set LNCS 15916,15917 & 15918 constitutes the refereed proceedings of the 29th Annual Conference on Medical Image Understanding and Analysis, MIUA 2025, held in Leeds, UK, during July 15-17, 2025.

The 67 revised full papers presented in these proceedings were carefully reviewed and selected from 99 submissions. The papers are organized in the following topical sections:

Part I: Frontiers in Computational Pathology; and Image Synthesis and Generative Artificial Intelligence.

Part II: Image-guided Diagnosis; and Image-guided Intervention.

Part III: Medical Image Segmentation; and Retinal and Vascular Image Analysis.