Infection is a major cause of morbidity and mortality in patients with neoplastic disease because of compromised host defenses. These defects result in an increased risk of infection and its complications. The nature of the underlying malignancy, the immunodeficiencies associated with it, and the treatments directed against it are all important determinants of infection. In recent years, the introduction of more intensive chemotherapeutic regimes and the widespread use of bone marrow and peripheral stem cell transplantation have changed the pattern of infection in many patients. Furthermore, the increasing use of central venous access devices and antimicrobial prophylaxis has changed the epidemiology of infection in these patients as well. The goal of this volume in the Cancer Treatment and Research series is to emphasize that while the management of infection in cancer patients is common, it is constantly changing. With the increasing complexity of these patients, optimal management requires a multidisciplinary approach. Ultimately, it is hoped that this book will assist clinicians in the diagnosis, management, and prevention of infection in order to optimize care for patients with cancer.

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Preface. 1. Host Impairments in Patients with Neoplastic Diseases; B.E. Depauw, et al. 2. The Epidemiology of Infectious Complications in Cancer Patients; T. Zembower. 3. Approach to Fever in the Neutropenic Host; A. Stoupis, S.H. Zinner. 4. Infections Associated with Solid Tumors; S.H. Sutton, J.P. Flaherty. 5. Role of the Clinical Microbiology Laboratory in the Diagnosis of Infections; R.B. Thomson, Jr., L.R. Peterson. 6. Recent Advances in the Management of Fungal Infections; J. Sanchez, G.A. Noskin. 7. Recent Advances in the Management of Viral Infections; J.R. Wingard. 8. Cytokines and Biological Response Modifiers in the Treatment of Infection; B.U. Mueller, P.A. Pizzo. 9. Prevention of Infection in Immunocompromised Hosts; G.A. Noskin. 10. Pharmacologic Considerations with Antimicrobials Used in Oncology; M. Postelnick, S.R. Halbur. 11. Economic Impact of Infections in Patients with Cancer; D.J. Shulkin, L.J. Anastasi. Index.